IgD myeloma. Report of a case with unusual clinical and immunologic features

R. Valenzuela, S. Govindarajan, R. Tubbs, S. Deodhar, R. Bukowski

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6 Scopus citations


A case of IgD myeloma in a 48-year-old Caucasian man is reported. The osteolytic features of this case included the absence of esteolytic lesions by x-ray, absence of anemia, absence of monoclonal spike on serum electrophoresis, association of kappa light chains, absence of Bence Jones proteinemia and Bence Jones proteinuria, and a remarkable, temporary clinical response to therapy. Immunoelectrophoresis of whole serum yielded a pattern consistent with IgD kappa monoclonal gammopathy. Immunoelectrophoresis of a pure serum IgD preparation, previously separated by gel chromatography (Sephadex G-200), revealed definitive information about an IgD kappa monoclonal gammopathy. Immunomicroscopic examination of bone-marrow smears showed the presence of delta and kappa chains only in the cytoplasm of plasma cells.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalAmerican journal of clinical pathology
Issue number2
StatePublished - 1979

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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