TY - JOUR
T1 - IgD myeloma. Report of a case with unusual clinical and immunologic features
AU - Valenzuela, R.
AU - Govindarajan, S.
AU - Tubbs, R.
AU - Deodhar, S.
AU - Bukowski, R.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - A case of IgD myeloma in a 48-year-old Caucasian man is reported. The osteolytic features of this case included the absence of esteolytic lesions by x-ray, absence of anemia, absence of monoclonal spike on serum electrophoresis, association of kappa light chains, absence of Bence Jones proteinemia and Bence Jones proteinuria, and a remarkable, temporary clinical response to therapy. Immunoelectrophoresis of whole serum yielded a pattern consistent with IgD kappa monoclonal gammopathy. Immunoelectrophoresis of a pure serum IgD preparation, previously separated by gel chromatography (Sephadex G-200), revealed definitive information about an IgD kappa monoclonal gammopathy. Immunomicroscopic examination of bone-marrow smears showed the presence of delta and kappa chains only in the cytoplasm of plasma cells.
AB - A case of IgD myeloma in a 48-year-old Caucasian man is reported. The osteolytic features of this case included the absence of esteolytic lesions by x-ray, absence of anemia, absence of monoclonal spike on serum electrophoresis, association of kappa light chains, absence of Bence Jones proteinemia and Bence Jones proteinuria, and a remarkable, temporary clinical response to therapy. Immunoelectrophoresis of whole serum yielded a pattern consistent with IgD kappa monoclonal gammopathy. Immunoelectrophoresis of a pure serum IgD preparation, previously separated by gel chromatography (Sephadex G-200), revealed definitive information about an IgD kappa monoclonal gammopathy. Immunomicroscopic examination of bone-marrow smears showed the presence of delta and kappa chains only in the cytoplasm of plasma cells.
UR - http://www.scopus.com/inward/record.url?scp=0018691566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018691566&partnerID=8YFLogxK
U2 - 10.1093/ajcp/72.2.246
DO - 10.1093/ajcp/72.2.246
M3 - Article
C2 - 112852
AN - SCOPUS:0018691566
VL - 72
SP - 246
EP - 250
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 2
ER -