IgCAMs: Bidirectional signals underlying neurite growth

Hiroyuki Kamiguchi, Vance Lemmon

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

Understanding how immunoglobulin superfamily cell adhesion molecules (IgCAMs) regulate nervous system development has lagged behind studies on integrins and cadherins. The recent characterization of IgCAM structures combined with cell biological studies on protein-protein interactions and membrane targeting/trafficking demonstrate that IgCAMs interact in exceedingly complex ways to regulate axonal growth and pathfinding.

Original languageEnglish (US)
Pages (from-to)598-605
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume12
Issue number5
DOIs
StatePublished - Jan 1 2000

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ASJC Scopus subject areas

  • Cell Biology

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