Abstract
A large number of cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IGSF) have been localized to the vertebrate nervous system, and the presence of unique combinations of domains in their molecular structures suggests distinct functions. The presence of many IGSF members on growing axons suggests a role for these molecules in axonal pathfinding and targeting. Nevertheless, the precise nature of that role is only now beginning to unfold. In this review, we will discuss the molecular structure, binding preference and potential signaling capabilities of IGSF CAMs expressed in the nervous system, with emphasis on studies of neurite outgrowth. In addition, the importance of naturally occurring mutations in one of these CAMs, L1, in human brain development will be described.
| Original language | English |
|---|---|
| Pages (from-to) | 79-87 |
| Number of pages | 9 |
| Journal | Seminars in Developmental Biology |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1995 |
| Externally published | Yes |
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Keywords
- axon guidance
- cell adhesion molecule
- MASA syndrome
- X-linked hydrocephalus
- X-linked spastic paraplegia
Cite this
Ig superfamily adhesion molecules in the vertebrate nervous system : binding partners and signal transduction during axon growth. / Burden-Gulley, Susan M.; Lemmon, Vance.
In: Seminars in Developmental Biology, Vol. 6, No. 2, 01.01.1995, p. 79-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ig superfamily adhesion molecules in the vertebrate nervous system
T2 - binding partners and signal transduction during axon growth
AU - Burden-Gulley, Susan M.
AU - Lemmon, Vance
PY - 1995/1/1
Y1 - 1995/1/1
N2 - A large number of cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IGSF) have been localized to the vertebrate nervous system, and the presence of unique combinations of domains in their molecular structures suggests distinct functions. The presence of many IGSF members on growing axons suggests a role for these molecules in axonal pathfinding and targeting. Nevertheless, the precise nature of that role is only now beginning to unfold. In this review, we will discuss the molecular structure, binding preference and potential signaling capabilities of IGSF CAMs expressed in the nervous system, with emphasis on studies of neurite outgrowth. In addition, the importance of naturally occurring mutations in one of these CAMs, L1, in human brain development will be described.
AB - A large number of cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IGSF) have been localized to the vertebrate nervous system, and the presence of unique combinations of domains in their molecular structures suggests distinct functions. The presence of many IGSF members on growing axons suggests a role for these molecules in axonal pathfinding and targeting. Nevertheless, the precise nature of that role is only now beginning to unfold. In this review, we will discuss the molecular structure, binding preference and potential signaling capabilities of IGSF CAMs expressed in the nervous system, with emphasis on studies of neurite outgrowth. In addition, the importance of naturally occurring mutations in one of these CAMs, L1, in human brain development will be described.
KW - axon guidance
KW - cell adhesion molecule
KW - MASA syndrome
KW - X-linked hydrocephalus
KW - X-linked spastic paraplegia
UR - http://www.scopus.com/inward/record.url?scp=0002398332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0002398332&partnerID=8YFLogxK
U2 - 10.1016/S1044-5781(06)80017-4
DO - 10.1016/S1044-5781(06)80017-4
M3 - Article
AN - SCOPUS:0002398332
VL - 6
SP - 79
EP - 87
JO - Seminars in Developmental Biology
JF - Seminars in Developmental Biology
SN - 1044-5781
IS - 2
ER -