TY - JOUR
T1 - Ig superfamily adhesion molecules in the vertebrate nervous system
T2 - binding partners and signal transduction during axon growth
AU - Burden-Gulley, Susan M.
AU - Lemmon, Vance
N1 - Funding Information:
The authors would like to acknowledge the assistance of H. Ross Payne in preparing the figures and also thank P. Doherty and P. Levitt for providing preprints. Work in the laboratory of V. Lemmon is supported by a grant from the National Eye Institute (EY05285).
PY - 1995/4
Y1 - 1995/4
N2 - A large number of cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IGSF) have been localized to the vertebrate nervous system, and the presence of unique combinations of domains in their molecular structures suggests distinct functions. The presence of many IGSF members on growing axons suggests a role for these molecules in axonal pathfinding and targeting. Nevertheless, the precise nature of that role is only now beginning to unfold. In this review, we will discuss the molecular structure, binding preference and potential signaling capabilities of IGSF CAMs expressed in the nervous system, with emphasis on studies of neurite outgrowth. In addition, the importance of naturally occurring mutations in one of these CAMs, L1, in human brain development will be described.
AB - A large number of cell adhesion molecules (CAMs) of the immunoglobulin superfamily (IGSF) have been localized to the vertebrate nervous system, and the presence of unique combinations of domains in their molecular structures suggests distinct functions. The presence of many IGSF members on growing axons suggests a role for these molecules in axonal pathfinding and targeting. Nevertheless, the precise nature of that role is only now beginning to unfold. In this review, we will discuss the molecular structure, binding preference and potential signaling capabilities of IGSF CAMs expressed in the nervous system, with emphasis on studies of neurite outgrowth. In addition, the importance of naturally occurring mutations in one of these CAMs, L1, in human brain development will be described.
KW - axon guidance
KW - cell adhesion molecule
KW - MASA syndrome
KW - X-linked hydrocephalus
KW - X-linked spastic paraplegia
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U2 - 10.1016/S1044-5781(06)80017-4
DO - 10.1016/S1044-5781(06)80017-4
M3 - Article
AN - SCOPUS:0002398332
VL - 6
SP - 79
EP - 87
JO - Seminars in Developmental Biology
JF - Seminars in Developmental Biology
SN - 1044-5781
IS - 2
ER -