Abstract
Membranous nephropathy (MN) is a glomerular disease due to subepithelial immune deposits and local complement activation resulting in podocyte injury and proteinuria. Patients with idiopathic (but not secondary) MN had circulating autoantibodies, predominantly of the IgG4 subclass, directed against M-type phospholipase A2 receptor (PLA2R) located on podocytes. It is also possible that the binding of anti-PLA2R antibodies to PLA2R on podocytes could alter receptor function resulting in podocyte dysfunction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-216 |
| Number of pages | 3 |
| Journal | Journal of Nephropathology |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2013 |
Fingerprint
Keywords
- Anti-phospholipase A2 receptor antibodies
- End-stage renal disease
- Idiopathic membranous nephropathy
- Nephrotic syndrome
ASJC Scopus subject areas
- Nephrology
Cite this
Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies. / Nayer, Ali; Asif, Arif.
In: Journal of Nephropathology, Vol. 2, No. 4, 2013, p. 214-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies
AU - Nayer, Ali
AU - Asif, Arif
PY - 2013
Y1 - 2013
N2 - Membranous nephropathy (MN) is a glomerular disease due to subepithelial immune deposits and local complement activation resulting in podocyte injury and proteinuria. Patients with idiopathic (but not secondary) MN had circulating autoantibodies, predominantly of the IgG4 subclass, directed against M-type phospholipase A2 receptor (PLA2R) located on podocytes. It is also possible that the binding of anti-PLA2R antibodies to PLA2R on podocytes could alter receptor function resulting in podocyte dysfunction.
AB - Membranous nephropathy (MN) is a glomerular disease due to subepithelial immune deposits and local complement activation resulting in podocyte injury and proteinuria. Patients with idiopathic (but not secondary) MN had circulating autoantibodies, predominantly of the IgG4 subclass, directed against M-type phospholipase A2 receptor (PLA2R) located on podocytes. It is also possible that the binding of anti-PLA2R antibodies to PLA2R on podocytes could alter receptor function resulting in podocyte dysfunction.
KW - Anti-phospholipase A2 receptor antibodies
KW - End-stage renal disease
KW - Idiopathic membranous nephropathy
KW - Nephrotic syndrome
UR - http://www.scopus.com/inward/record.url?scp=84881124187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881124187&partnerID=8YFLogxK
U2 - 10.12860/JNP.2013.35
DO - 10.12860/JNP.2013.35
M3 - Article
AN - SCOPUS:84881124187
VL - 2
SP - 214
EP - 216
JO - Journal of Nephropathology
JF - Journal of Nephropathology
SN - 2251-8363
IS - 4
ER -