Membranous nephropathy (MN) is a glomerular disease due to subepithelial immune deposits and local complement activation resulting in podocyte injury and proteinuria. Patients with idiopathic (but not secondary) MN had circulating autoantibodies, predominantly of the IgG4 subclass, directed against M-type phospholipase A2 receptor (PLA2R) located on podocytes. It is also possible that the binding of anti-PLA2R antibodies to PLA2R on podocytes could alter receptor function resulting in podocyte dysfunction.
- Anti-phospholipase A2 receptor antibodies
- End-stage renal disease
- Idiopathic membranous nephropathy
- Nephrotic syndrome
ASJC Scopus subject areas