Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies

Ali Nayer, Arif Asif

Research output: Contribution to journalEditorialpeer-review

4 Scopus citations


Membranous nephropathy (MN) is a glomerular disease due to subepithelial immune deposits and local complement activation resulting in podocyte injury and proteinuria. Patients with idiopathic (but not secondary) MN had circulating autoantibodies, predominantly of the IgG4 subclass, directed against M-type phospholipase A2 receptor (PLA2R) located on podocytes. It is also possible that the binding of anti-PLA2R antibodies to PLA2R on podocytes could alter receptor function resulting in podocyte dysfunction.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalJournal of Nephropathology
Issue number4
StatePublished - Jan 1 2013


  • Anti-phospholipase A2 receptor antibodies
  • End-stage renal disease
  • Idiopathic membranous nephropathy
  • Nephrotic syndrome

ASJC Scopus subject areas

  • Nephrology


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