Abstract
Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.
| Original language | English |
|---|---|
| Pages (from-to) | 1399-1406 |
| Number of pages | 8 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 55 |
| Issue number | 11 |
| DOIs | |
| State | Published - Aug 30 1999 |
| Externally published | Yes |
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Keywords
- Axon
- Chemoaffinity
- Growth cone
- Molecular integration
- Neural recognition
- Synaptogenesis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
Cite this
'Identify' and 'lock in' : Molecular integration during synaptic target recognition. / Hoang, B.; Chiba, Akira.
In: Cellular and Molecular Life Sciences, Vol. 55, No. 11, 30.08.1999, p. 1399-1406.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 'Identify' and 'lock in'
T2 - Molecular integration during synaptic target recognition
AU - Hoang, B.
AU - Chiba, Akira
PY - 1999/8/30
Y1 - 1999/8/30
N2 - Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.
AB - Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.
KW - Axon
KW - Chemoaffinity
KW - Growth cone
KW - Molecular integration
KW - Neural recognition
KW - Synaptogenesis
UR - http://www.scopus.com/inward/record.url?scp=0033618880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033618880&partnerID=8YFLogxK
U2 - 10.1007/s000180050380
DO - 10.1007/s000180050380
M3 - Article
C2 - 10518989
AN - SCOPUS:0033618880
VL - 55
SP - 1399
EP - 1406
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 11
ER -