'Identify' and 'lock in': Molecular integration during synaptic target recognition

B. Hoang, Akira Chiba

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.

Original languageEnglish
Pages (from-to)1399-1406
Number of pages8
JournalCellular and Molecular Life Sciences
Volume55
Issue number11
DOIs
StatePublished - Aug 30 1999
Externally publishedYes

Fingerprint

Presynaptic Terminals
Molecules

Keywords

  • Axon
  • Chemoaffinity
  • Growth cone
  • Molecular integration
  • Neural recognition
  • Synaptogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

'Identify' and 'lock in' : Molecular integration during synaptic target recognition. / Hoang, B.; Chiba, Akira.

In: Cellular and Molecular Life Sciences, Vol. 55, No. 11, 30.08.1999, p. 1399-1406.

Research output: Contribution to journalArticle

@article{3baafa8e1418497e9477b5ce7a0dbfae,
title = "'Identify' and 'lock in': Molecular integration during synaptic target recognition",
abstract = "Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.",
keywords = "Axon, Chemoaffinity, Growth cone, Molecular integration, Neural recognition, Synaptogenesis",
author = "B. Hoang and Akira Chiba",
year = "1999",
month = "8",
day = "30",
doi = "10.1007/s000180050380",
language = "English",
volume = "55",
pages = "1399--1406",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "11",

}

TY - JOUR

T1 - 'Identify' and 'lock in'

T2 - Molecular integration during synaptic target recognition

AU - Hoang, B.

AU - Chiba, Akira

PY - 1999/8/30

Y1 - 1999/8/30

N2 - Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.

AB - Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.

KW - Axon

KW - Chemoaffinity

KW - Growth cone

KW - Molecular integration

KW - Neural recognition

KW - Synaptogenesis

UR - http://www.scopus.com/inward/record.url?scp=0033618880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033618880&partnerID=8YFLogxK

U2 - 10.1007/s000180050380

DO - 10.1007/s000180050380

M3 - Article

C2 - 10518989

AN - SCOPUS:0033618880

VL - 55

SP - 1399

EP - 1406

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 11

ER -