'Identify' and 'lock in': Molecular integration during synaptic target recognition

B. Hoang, A. Chiba

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.

Original languageEnglish (US)
Pages (from-to)1399-1406
Number of pages8
JournalCellular and Molecular Life Sciences
Volume55
Issue number11
DOIs
StatePublished - Aug 30 1999
Externally publishedYes

Keywords

  • Axon
  • Chemoaffinity
  • Growth cone
  • Molecular integration
  • Neural recognition
  • Synaptogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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