'Identify' and 'lock in': Molecular integration during synaptic target recognition

B. Hoang; A. Chiba

doi:10.1007/s000180050380

'Identify' and 'lock in': Molecular integration during synaptic target recognition

B. Hoang, A. Chiba

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.

Original language	English (US)
Pages (from-to)	1399-1406
Number of pages	8
Journal	Cellular and Molecular Life Sciences
Volume	55
Issue number	11
DOIs	https://doi.org/10.1007/s000180050380
State	Published - Aug 30 1999
Externally published	Yes

Keywords

Axon
Chemoaffinity
Growth cone
Molecular integration
Neural recognition
Synaptogenesis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Cell Biology

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10.1007/s000180050380

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abstract = "Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.",

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T1 - 'Identify' and 'lock in'

T2 - Molecular integration during synaptic target recognition

AU - Hoang, B.

AU - Chiba, A.

PY - 1999/8/30

Y1 - 1999/8/30

N2 - Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.

AB - Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.

KW - Axon

KW - Chemoaffinity

KW - Growth cone

KW - Molecular integration

KW - Neural recognition

KW - Synaptogenesis

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DO - 10.1007/s000180050380

M3 - Review article

C2 - 10518989

AN - SCOPUS:0033618880

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JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 11

ER -

'Identify' and 'lock in': Molecular integration during synaptic target recognition

Abstract

Keywords

ASJC Scopus subject areas

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