Abstract
Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively 'rare' molecules first detect the cell identity of the synaptic target. Subsequently, many 'common' molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.
Original language | English (US) |
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Pages (from-to) | 1399-1406 |
Number of pages | 8 |
Journal | Cellular and Molecular Life Sciences |
Volume | 55 |
Issue number | 11 |
DOIs | |
State | Published - Aug 30 1999 |
Externally published | Yes |
Keywords
- Axon
- Chemoaffinity
- Growth cone
- Molecular integration
- Neural recognition
- Synaptogenesis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology