Abstract
Objectives: To identify the factors determining a high recombinant human erythropoietin (rHuEPO) dose requirement and associated side effects in children undergoing hemodialysis. Study design: We retrospectively analyzed the clinical data of 23 children (aged 5-20 years) undergoing long-term hemodialysis. All subjects received intravenous rHuEPO to maintain hemoglobin levels ≥10 g/dL and had iron supplement. Subjects were divided into 2 groups: those receiving high-dose rHuEPO (≥450 U/kg/wk) and those receiving an average dose (<450 U/kg/wk). We compared the specific variables between both groups by using Mann-Whitney, Fisher exact, and linear regression tests; a P value <.05 was considered significant. Results: Four of 23 subjects (17%) received high-dose rHuEPO despite iron repletion. These subjects were small and young and had frequent bacterial infections, high ferritin levels, and severe hyperparathyroidism. Two patients with human immunodeficiency virus infection required high-dose rHuEPO. The main adverse effect of high-dose rHuEPO was an increase in the heparin requirement during hemodialysis. Conclusions: Age, body weight, inflammatory status, and severity of hyperparathyroidism should be taken into account when adjusting rHuEPO dose for children undergoing hemodialysis. Furthermore, we suggest that high rHuEPO doses are related to an increase in the heparin requirement in these children.
| Original language | English |
|---|---|
| Pages (from-to) | 710-714 |
| Number of pages | 5 |
| Journal | Journal of Pediatrics |
| Volume | 138 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 20 2001 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Identification of poor responders to erythropoietin among children undergoing hemodialysis. / Seeherunvong, Wacharee; Rubio, Liliana; Abitbol, Carolyn; Montané, Brenda; Strauss, Jose; Diaz, Rosa; Zilleruelo, Gaston E.
In: Journal of Pediatrics, Vol. 138, No. 5, 20.05.2001, p. 710-714.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of poor responders to erythropoietin among children undergoing hemodialysis
AU - Seeherunvong, Wacharee
AU - Rubio, Liliana
AU - Abitbol, Carolyn
AU - Montané, Brenda
AU - Strauss, Jose
AU - Diaz, Rosa
AU - Zilleruelo, Gaston E
PY - 2001/5/20
Y1 - 2001/5/20
N2 - Objectives: To identify the factors determining a high recombinant human erythropoietin (rHuEPO) dose requirement and associated side effects in children undergoing hemodialysis. Study design: We retrospectively analyzed the clinical data of 23 children (aged 5-20 years) undergoing long-term hemodialysis. All subjects received intravenous rHuEPO to maintain hemoglobin levels ≥10 g/dL and had iron supplement. Subjects were divided into 2 groups: those receiving high-dose rHuEPO (≥450 U/kg/wk) and those receiving an average dose (<450 U/kg/wk). We compared the specific variables between both groups by using Mann-Whitney, Fisher exact, and linear regression tests; a P value <.05 was considered significant. Results: Four of 23 subjects (17%) received high-dose rHuEPO despite iron repletion. These subjects were small and young and had frequent bacterial infections, high ferritin levels, and severe hyperparathyroidism. Two patients with human immunodeficiency virus infection required high-dose rHuEPO. The main adverse effect of high-dose rHuEPO was an increase in the heparin requirement during hemodialysis. Conclusions: Age, body weight, inflammatory status, and severity of hyperparathyroidism should be taken into account when adjusting rHuEPO dose for children undergoing hemodialysis. Furthermore, we suggest that high rHuEPO doses are related to an increase in the heparin requirement in these children.
AB - Objectives: To identify the factors determining a high recombinant human erythropoietin (rHuEPO) dose requirement and associated side effects in children undergoing hemodialysis. Study design: We retrospectively analyzed the clinical data of 23 children (aged 5-20 years) undergoing long-term hemodialysis. All subjects received intravenous rHuEPO to maintain hemoglobin levels ≥10 g/dL and had iron supplement. Subjects were divided into 2 groups: those receiving high-dose rHuEPO (≥450 U/kg/wk) and those receiving an average dose (<450 U/kg/wk). We compared the specific variables between both groups by using Mann-Whitney, Fisher exact, and linear regression tests; a P value <.05 was considered significant. Results: Four of 23 subjects (17%) received high-dose rHuEPO despite iron repletion. These subjects were small and young and had frequent bacterial infections, high ferritin levels, and severe hyperparathyroidism. Two patients with human immunodeficiency virus infection required high-dose rHuEPO. The main adverse effect of high-dose rHuEPO was an increase in the heparin requirement during hemodialysis. Conclusions: Age, body weight, inflammatory status, and severity of hyperparathyroidism should be taken into account when adjusting rHuEPO dose for children undergoing hemodialysis. Furthermore, we suggest that high rHuEPO doses are related to an increase in the heparin requirement in these children.
UR - http://www.scopus.com/inward/record.url?scp=0035025315&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035025315&partnerID=8YFLogxK
U2 - 10.1067/mpd.2001.112246
DO - 10.1067/mpd.2001.112246
M3 - Article
C2 - 11343048
AN - SCOPUS:0035025315
VL - 138
SP - 710
EP - 714
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -