Identification of new translocation breakpoints at 12q13 in lipomas

Sandra Merscher, Ivonne Marondel, Florence Pedeutour, Patrick Gaudray, Raju Kucherlapati, Claude Turc-Carel

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Cytogenetic studies of banded chromosomes and fluorescence in situ hybridization (FISH) of several yeast artificial chromosomes (YACs) that are part of a 128-kb resolution physical map of a portion of 12q13 revealed that 4/14 (28%) lipomas have breakpoints in 12q13. These breakpoints are more than 10 Mb away from the HMGIC gene at 12q14-q15, which is known to be modified in some lipomas. FISH with individual YACs at 12q13 enabled us to identify four YACs that span three breakpoints. Our results suggest that genes other than HMGIC on human chromosome 12 may be involved in the etiology of lipoma development.

Original languageEnglish (US)
Pages (from-to)70-77
Number of pages8
JournalGenomics
Volume46
Issue number1
DOIs
StatePublished - Nov 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Merscher, S., Marondel, I., Pedeutour, F., Gaudray, P., Kucherlapati, R., & Turc-Carel, C. (1997). Identification of new translocation breakpoints at 12q13 in lipomas. Genomics, 46(1), 70-77. https://doi.org/10.1006/geno.1997.4993