Identification of monosodium urate crystal deposits in patients with asymptomatic hyperuricemia using dual-energy CT

Penny Wang, Stacy E. Smith, Rajesh Garg, Fengxin Lu, Alyssa Wohlfahrt, Anarosa Campos, Kathleen Vanni, Zhi Yu, Daniel H. Solomon, Seoyoung C. Kim

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objectives Dual-energy CT (DECT) scan is a sensitive and specific tool used to visualise and quantify monosodium urate (MSU) crystal deposits in the joints. Few studies have examined MSU crystal deposits in patients with asymptomatic hyperuricemia (ie, hyperuricemia in the absence of gout) using DECT. Methods We conducted a prospective, non-interventional cross-sectional study to detect MSU crystal deposits on DECT scans among patients with asymptomatic hyperuricemia. We also examined patient factors associated with subclinical MSU crystal deposits. Out of 130 subjects aged ≥40 years with metabolic syndrome screened for serum uric acid (sUA) levels ≥6.5 mg/dL, 46 underwent a foot/ankle DECT scan. Results The mean age of the study participants was 62 (±8) years, 41% were men and the mean sUA level was 7.8 (±1.0) mg/dL. Seven (15%) of 46 patients had MSU crystal deposits on DECT with a mean total volume of 0.13 (±0.14) cm 3. In the univariable logistic regression analysis, older age had a significant association with presence of MSU crystal deposits (OR 1.20, 95% CI 1.03 to 1.39), but sUA did not (OR 1.36, 95% CI 0.63 to 2.95). In the univariable analysis, sUA levels showed a trend towards a modest linear association (β=0.11, P=0.09) with total volume of MSU crystal deposits. Conclusions Fifteen per cent of patients with asymptomatic hyperuricemia had subclinical MSU crystal deposits on foot/ankle DECT scans. Older age, but not sUA, was significantly associated with presence of subclinical MSU crystal deposits among patients with asymptomatic hyperuricemia. Clinical significance of these subclinical MSU crystal deposits needs to be determined.

Original languageEnglish (US)
Article numbere000593
JournalRMD Open
Volume4
Issue number1
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • gout
  • inflammation
  • synovial fluid

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Fingerprint

Dive into the research topics of 'Identification of monosodium urate crystal deposits in patients with asymptomatic hyperuricemia using dual-energy CT'. Together they form a unique fingerprint.

Cite this