Identification of KANSARL as the first cancer predisposition fusion gene specific to the population of European ancestry originw

Jeff Xiwu Zhou, Xiaoyan Yang, Shunbin Ning, Ling Wang, Kesheng Wang, Yanbin Zhang, Fenghua Yuan, Fengli Li, David D. Zhuo, Liren Tang, Degen Zhuo

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Gene fusion is one of the hallmarks of cancer. Recent advances in RNA-seq of cancer transcriptomes have facilitated the discovery of fusion transcripts. In this study, we report identification of a surprisingly large number of fusion transcripts, including six KANSARL (KANSL1-ARL17A) transcripts that resulted from the fusion between the KANSL1 and ARL17A genes using a RNA splicingcode model. Five of these six KANSARL fusion transcripts are novel. By systematic analysis of RNA-seq data of glioblastoma, prostate cancer, lung cancer, breast cancer, and lymphoma from different regions of the World, we have found that KANSARL fusion transcripts were rarely detected in the tumors of individuals from Asia or Africa. In contrast, they exist in 30 - 52% of the tumors from North Americans cancer patients. Analysis of CEPH/ Utah Pedigree 1463 has revealed that KANSARL is a familially-inherited fusion gene. Further analysis of RNA-seq datasets of the 1000 Genome Project has indicated that KANSARL fusion gene is specific to 28.9% of the population of European ancestry origin. In summary, we demonstrated that KANSARL is the first cancer predisposition fusion gene associated with genetic backgrounds of European ancestry origin.

Original languageEnglish (US)
Pages (from-to)50594-50607
Number of pages14
JournalOncotarget
Volume8
Issue number31
DOIs
StatePublished - Feb 7 2017

Keywords

  • European ancestry origin
  • Fusion gene
  • KANSARL
  • RNA-seq

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Zhou, J. X., Yang, X., Ning, S., Wang, L., Wang, K., Zhang, Y., Yuan, F., Li, F., Zhuo, D. D., Tang, L., & Zhuo, D. (2017). Identification of KANSARL as the first cancer predisposition fusion gene specific to the population of European ancestry originw. Oncotarget, 8(31), 50594-50607. https://doi.org/10.18632/oncotarget.16385