Identification of human trophoblast membrane antigens in maternal blood during pregnancy

M. J. O'Sullivan, J. A. McIntyre, M. Prior, G. Warriner, W. P. Faulk

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The development of an immunoradiometric assay for the detection of human trophoblast-specific membrane antigens is described The test revealed for the first time circulating trophoblast-specific cell membrane antigens in the peripheral blood of pregnant women, but none in non-pregnant female or male controls. Comparison of the circulating levels of these trophoblast specific proteins between normal and pre-eclamptic blood samples showed no significant differences, thus casting doubt on the role of differential trophoblast antigen deportation in the etiology of toxaemic pregnancy. Matched retroplacental cord blood from several normal and pre-eclamptic pregnancies were examined and found either negative or near the lower sensitivity limit of the assay, suggesting that deportation of trophoblast membrane antigens during gestation is limited to the maternal aspect of the placenta.

Original languageEnglish (US)
Pages (from-to)279-287
Number of pages9
JournalClinical and Experimental Immunology
Volume48
Issue number1
StatePublished - Jun 4 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    O'Sullivan, M. J., McIntyre, J. A., Prior, M., Warriner, G., & Faulk, W. P. (1982). Identification of human trophoblast membrane antigens in maternal blood during pregnancy. Clinical and Experimental Immunology, 48(1), 279-287.