Identification of human trophoblast membrane antigens in maternal blood during pregnancy

M. J. O'Sullivan, J. A. McIntyre, M. Prior, G. Warriner, W. P. Faulk

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The development of an immunoradiometric assay for the detection of human trophoblast-specific membrane antigens is described The test revealed for the first time circulating trophoblast-specific cell membrane antigens in the peripheral blood of pregnant women, but none in non-pregnant female or male controls. Comparison of the circulating levels of these trophoblast specific proteins between normal and pre-eclamptic blood samples showed no significant differences, thus casting doubt on the role of differential trophoblast antigen deportation in the etiology of toxaemic pregnancy. Matched retroplacental cord blood from several normal and pre-eclamptic pregnancies were examined and found either negative or near the lower sensitivity limit of the assay, suggesting that deportation of trophoblast membrane antigens during gestation is limited to the maternal aspect of the placenta.

Original languageEnglish
Pages (from-to)279-287
Number of pages9
JournalClinical and Experimental Immunology
Volume48
Issue number1
StatePublished - Jun 4 1982
Externally publishedYes

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Forensic Anthropology
Trophoblasts
Mothers
Antigens
Pregnancy
Membranes
Immunoradiometric Assay
Fetal Blood
Placenta
Pregnant Women
Cell Membrane
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

O'Sullivan, M. J., McIntyre, J. A., Prior, M., Warriner, G., & Faulk, W. P. (1982). Identification of human trophoblast membrane antigens in maternal blood during pregnancy. Clinical and Experimental Immunology, 48(1), 279-287.

Identification of human trophoblast membrane antigens in maternal blood during pregnancy. / O'Sullivan, M. J.; McIntyre, J. A.; Prior, M.; Warriner, G.; Faulk, W. P.

In: Clinical and Experimental Immunology, Vol. 48, No. 1, 04.06.1982, p. 279-287.

Research output: Contribution to journalArticle

O'Sullivan, MJ, McIntyre, JA, Prior, M, Warriner, G & Faulk, WP 1982, 'Identification of human trophoblast membrane antigens in maternal blood during pregnancy', Clinical and Experimental Immunology, vol. 48, no. 1, pp. 279-287.
O'Sullivan MJ, McIntyre JA, Prior M, Warriner G, Faulk WP. Identification of human trophoblast membrane antigens in maternal blood during pregnancy. Clinical and Experimental Immunology. 1982 Jun 4;48(1):279-287.
O'Sullivan, M. J. ; McIntyre, J. A. ; Prior, M. ; Warriner, G. ; Faulk, W. P. / Identification of human trophoblast membrane antigens in maternal blood during pregnancy. In: Clinical and Experimental Immunology. 1982 ; Vol. 48, No. 1. pp. 279-287.
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