Identification of human immunodeficiency virus-1 RNA and DNA in the heart of a child with cardiovascular abnormalities and congenital acquired immune deficiency syndrome

Steven E. Lipshultz, Cecil H. Fox, Antonio R. Perez-Atayde, Stephen P. Sanders, Steven D. Colan, Kenneth McIntosh, Harland S. Winter

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Abnormalities of the heart are common in infants and children congenitally infected with the human immunodeficiency virus-1 (HIV-1). Enhanced left ventricular performance, abnormal contractility1 and increased heart mass2 are the most common of these manifestations. The etiology of these abnormalities is obscure because there is no obvious histologic or ultrastructural explanation for their presence.1 HIV-1 has been detected by Southern blot and cultivated from homogenized myocardium,3,4 but these techniques are incapable of determining the precise location of viral expression or proviral deoxyribonucleic acid (DNA) within the tissue. Using molecular techniques, we have undertaken a detailed study of 1 patient to establish the presence of HIV in myocardium and the distribution of cells producing viral ribonucleic acid (RNA) in the heart muscle.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalThe American Journal of Cardiology
Volume66
Issue number2
DOIs
StatePublished - Jul 15 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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