Identification of filamin-A and -B as potential biomarkers for prostate cancer

Niven R. Narain, Anne R. Diers, Arleide Lee, Socheata Lao, Joyce Y. Chan, Sally Schofield, Joe Andreazi, Rakibou Ouro-Djobo, Joaquin J Jimenez, Tracey Friss, Nikunj Tanna, Aditee Dalvi, Sihe Wang, Dustin Bunch, Yezhou Sun, Wenfang Wu, Khampaseuth Thapa, Stephane Gesta, Leonardo O. Rodrigues, Viatcheslav R. AkmaevVivek K. Vishnudas, Rangaprasad Sarangarajan

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A novel strategy for prostate cancer (PrCa) biomarker discovery is described. Materials & methods: In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens. Results: Filamin-B (FLNB) and Keratin-19 were identified as biomarkers. Filamin-A (FLNA) was found to be causally linked to FLNB. Characterization of the biomarkers in a panel of cells revealed differential mRNA expression and regulation. Moreover, FLNA and FLNB were detected in the conditioned media of cells. Last, in patients without PrCa, FLNA and FLNB blood levels were positively correlated, while in patients with adenocarcinoma the relationship is dysregulated. Conclusion: These data support the strategy and the potential use of the biomarkers for PrCa.

Original languageEnglish (US)
Article numberFSO161
JournalFuture Science OA
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2017

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Keywords

  • Bayesian network learning
  • Biomarkers
  • FLNA
  • FLNB
  • KRT19
  • Prostate cancer

ASJC Scopus subject areas

  • Biotechnology

Cite this

Narain, N. R., Diers, A. R., Lee, A., Lao, S., Chan, J. Y., Schofield, S., Andreazi, J., Ouro-Djobo, R., Jimenez, J. J., Friss, T., Tanna, N., Dalvi, A., Wang, S., Bunch, D., Sun, Y., Wu, W., Thapa, K., Gesta, S., Rodrigues, L. O., ... Sarangarajan, R. (2017). Identification of filamin-A and -B as potential biomarkers for prostate cancer. Future Science OA, 3(1), [FSO161]. https://doi.org/10.4155/fsoa-2016-0065