Identification of collagen subtypes in synovial fluid sediments from arthritic patients

Herman S Cheung, Lawrence M. Ryan, Franklin Kozin, Daniel J. McCarty

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Collagen fibers in synovial fluid sediment were described a decade ago. Since then, tissue-specific collagen molecules (types) have been characterized. Techniques were devised to identify the collagen types in joint fluid sediment. Collagens were found in 12 of 17 pellets prepared from fluid aspirates from 17 knee joints of patients with various forms of arthritis. Collagen types I and III and polypeptide chains A and B (basement membrane collagen) were specifically identified in four of seven fluids from patients with active systemic lupus erythematosus (SLE) and in a single fluid from a patient with severe septic arthritis. This "collagen profile" was identical to that of rheumatoid synovium. Type II collagen, characteristic of hyaline articular cartilage, was found in two of six fluids from osteoarthritic joints. The presence of sufficient collagen (about 5 μg) to permit typing was correlated with roentgenpgraphic evidence of joint space narrowing; the presence of the "synovial" collagen profile was correlated with decreased joint fluid pH.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalThe American Journal of Medicine
Volume68
Issue number1
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Synovial Fluid
Arthritis
Collagen
Joints
Hyaline Cartilage
Infectious Arthritis
Collagen Type III
Collagen Type II
Synovial Membrane
Articular Cartilage
Knee Joint
Collagen Type I
Basement Membrane
Systemic Lupus Erythematosus
Peptides

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Identification of collagen subtypes in synovial fluid sediments from arthritic patients. / Cheung, Herman S; Ryan, Lawrence M.; Kozin, Franklin; McCarty, Daniel J.

In: The American Journal of Medicine, Vol. 68, No. 1, 01.01.1980, p. 73-79.

Research output: Contribution to journalArticle

Cheung, Herman S ; Ryan, Lawrence M. ; Kozin, Franklin ; McCarty, Daniel J. / Identification of collagen subtypes in synovial fluid sediments from arthritic patients. In: The American Journal of Medicine. 1980 ; Vol. 68, No. 1. pp. 73-79.
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