Abstract
Growth cones sense cues by filopodial contact, but how their motility is altered by contact remains unclear. Although contact could alter motile dynamics in complex ways, our analysis shows that stable contact with Schwann cells induces motility changes that are remarkably discrete and invariant. Filopodial contact invariably induces local veil extension. Even when contacts are brief, veils always extend before the filopodia retract. Contact at filopodial tips suffices for induction. Moreover, veils extend significantly sooner than on filopodia contacting laminin, which often detach without extending veils. The overall behavioral responses of the growth cone, such as increased area and turning, result from integrating multiple discrete responses. Cycles of veil induction enlarge the growth cone and often lead it onto the cell. Invariant veil induction is abolished by blocking N-cadherin signaling. We propose an axonal guidance model in which different guidance cues act by inducing different but discrete and invariant responses.
| Original language | English |
|---|---|
| Pages (from-to) | 1044-1055 |
| Number of pages | 12 |
| Journal | Journal of Neuroscience |
| Volume | 20 |
| Issue number | 3 |
| State | Published - Feb 1 2000 |
| Externally published | Yes |
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Keywords
- Axonal guidance mechanisms
- Filopodia
- G-proteins
- Growth cones
- Guidance cues
- N-cadherin
- Pathfinding mechanisms
- Schwann-neurite interactions
- Sensory neuron guidance
- Veils
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Identification of an invariant response : Stable contact with Schwann cells induces veil extension in sensory growth cones. / Polinsky, Michael; Balazovich, Kenneth; Tosney, Kathryn.
In: Journal of Neuroscience, Vol. 20, No. 3, 01.02.2000, p. 1044-1055.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of an invariant response
T2 - Stable contact with Schwann cells induces veil extension in sensory growth cones
AU - Polinsky, Michael
AU - Balazovich, Kenneth
AU - Tosney, Kathryn
PY - 2000/2/1
Y1 - 2000/2/1
N2 - Growth cones sense cues by filopodial contact, but how their motility is altered by contact remains unclear. Although contact could alter motile dynamics in complex ways, our analysis shows that stable contact with Schwann cells induces motility changes that are remarkably discrete and invariant. Filopodial contact invariably induces local veil extension. Even when contacts are brief, veils always extend before the filopodia retract. Contact at filopodial tips suffices for induction. Moreover, veils extend significantly sooner than on filopodia contacting laminin, which often detach without extending veils. The overall behavioral responses of the growth cone, such as increased area and turning, result from integrating multiple discrete responses. Cycles of veil induction enlarge the growth cone and often lead it onto the cell. Invariant veil induction is abolished by blocking N-cadherin signaling. We propose an axonal guidance model in which different guidance cues act by inducing different but discrete and invariant responses.
AB - Growth cones sense cues by filopodial contact, but how their motility is altered by contact remains unclear. Although contact could alter motile dynamics in complex ways, our analysis shows that stable contact with Schwann cells induces motility changes that are remarkably discrete and invariant. Filopodial contact invariably induces local veil extension. Even when contacts are brief, veils always extend before the filopodia retract. Contact at filopodial tips suffices for induction. Moreover, veils extend significantly sooner than on filopodia contacting laminin, which often detach without extending veils. The overall behavioral responses of the growth cone, such as increased area and turning, result from integrating multiple discrete responses. Cycles of veil induction enlarge the growth cone and often lead it onto the cell. Invariant veil induction is abolished by blocking N-cadherin signaling. We propose an axonal guidance model in which different guidance cues act by inducing different but discrete and invariant responses.
KW - Axonal guidance mechanisms
KW - Filopodia
KW - G-proteins
KW - Growth cones
KW - Guidance cues
KW - N-cadherin
KW - Pathfinding mechanisms
KW - Schwann-neurite interactions
KW - Sensory neuron guidance
KW - Veils
UR - http://www.scopus.com/inward/record.url?scp=0034143227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034143227&partnerID=8YFLogxK
M3 - Article
C2 - 10648710
AN - SCOPUS:0034143227
VL - 20
SP - 1044
EP - 1055
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 3
ER -