Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein)

Marie W. Wooten, Andre E. Nel, Pascal J. Goldschmidt-Clermont, Robert M. Galbraith, Robert W. Wrenn

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A major 56 kDa substrate for phospholipid/Ca2+-dependent kinase (C-kinase) in pancreatic acinar cells is physicochemically and immunologically indistinguishable from the vitamin D-binding protein, Gc or group-specific component. Cellular Gc was also phosphorylated in intact cells following treatment with carbachol as a physiological stimulus. These findings indicate the potential usefulness of Gc as a defined substrate for further studies of the biological role of C-kinase activity in pancreatic acini and possibly in other cells.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalFEBS letters
Volume191
Issue number1
DOIs
StatePublished - Oct 21 1985

Keywords

  • C-kinase
  • Gc protein
  • Pancreatic acini

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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