@article{eb4b193feb8c411ebc509574f98264c7,
title = "Identification of a five-lncRNA signature for predicting the risk of tumor recurrence in patients with breast cancer",
abstract = "Long non-coding RNAs (lncRNAs) are a major class of non-coding RNAs, and the functional deregulations of lncRNAs have been shown to be associated with the development and progression of BC. In this work, we conduct an integrative analysis on five re-annotated lncRNA expression datasets from the Gene Expression Omnibus (GEO) which included a total of 891 BC samples. We identified a five-lncRNA signature that was significantly associated with DFS in the training cohort of 327 patients. We found the five-lncRNA signature could effectively stratify patients in the training dataset into high- and low-risk groups with significantly different DFS (p = 3.29 × 10−5, log-rank test). The five-lncRNA signature was effectively validated in four independent cohorts, and prognostic analysis results showed that the five-lncRNA signature was independent of clinical prognostic factors, such as BC subtypes and adjuvant treatments. Furthermore, GSEA suggested that the five-lncRNA signature was involved in BC metastasis-related pathways. Our findings indicate that these five lncRNAs may be implicated in BC pathogenesis, and further, these lncRNAs may potentially serve as novel candidate biomarkers for the identification of BC patients at high risk for tumor recurrence.",
keywords = "array re-annotation, breast cancer, lncRNA signature, prognosis, tumor recurrence",
author = "Jie Li and Weida Wang and Peng Xia and Linyun Wan and Li Zhang and Lei Yu and Lily Wang and Xi Chen and Yun Xiao and Chaohan Xu",
note = "Funding Information: Key words: lncRNA signature, prognosis, breast cancer, array re-annotation, tumor recurrence Abbreviations: AUC: an area under the ROC curve; BC: breast cancer; Cox PHR: Cox proportional hazards regression; DFS: disease-free survival; ER: Estrogen receptor; FDR: false discovery rate; GAS5: growth arrest-specific 5; GEO: gene expression omnibus; GSEA: gene set enrichment analysis; HOTAIR: HOX transcript antisense RNA; HR: hazard ratio;; LncRNAs: long non-coding RNAs; MALAT1: metastasis-associated lung adenocarcinoma transcript 1; OS: overall survival; PR: progesterone receptor; ROC: receiver operating characteristic Additional Supporting Information may be found in the online version of this article. †J.L., W.W., P.X., and L.W contributed equally to this work Grant sponsor: National High Technology Research and Development Program of China (863 Program); Grant number: 2014AA021102; Grant sponsor: National Program on Key Basic ResearchProject (973 Program); Grant number: 2014CB910504; Grant sponsor: The National Natural Science Foundation of China; Grant numbers: 91439117, 61473106, 61573122, 31601076; Grant sponsor: Wu Lien-Teh Youth Science Fund Project of Harbin Medical University; Grant number: WLD-QN1407; Grant sponsor: The Postdoctoral project of Heilongjiang Province; Grant number: LBH-Z14130; Grant sponsor: National Cancer Institute (USA); Grant numbers: R01CA200987, R01CA158472, U24CA210954 DOI: 10.1002/ijc.31573 History: Received 22 Sep 2017; Accepted 23 Apr 2018; Online 30 Apr 2018 Correspondence to: Chaohan Xu, College of Bioinformatics Science and Technology, Harbin Medical University, No. 194, Xue-Fu Road, Nangang Region, Harbin 150081, China, Tel.: 86-451-86615922, Fax: 86-451-86615922, E-mail: chaohanxu@hrbmu.edu.cn; or Yun Xiao, College of Bioinformatics Science and Technology, Harbin Medical University, No. 194, Xue-Fu Road, Nangang Region, Harbin 150081, China, Tel.: 86-451-86615922, Fax: 86-451-86615922, E-mail: xiaoyun@ems.hrbmu.edu.cn; or Xi Chen, Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14th Street, Clinical Research Building, Suite #1044, Miami, FL 33136, USA, Tel.: (305)-243-3081, E-mail: steven.chen@miami.edu",
year = "2018",
month = nov,
day = "1",
doi = "10.1002/ijc.31573",
language = "English (US)",
volume = "143",
pages = "2150--2160",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "9",
}