Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Daniele Passarella; Raffaele Favia; Alessandra Giardini; Giordano Lesma; Marisa Martinelli; Alessandra Silvani; Bruno Danieli; Simon M.N. Efange; Deborah C. Mash

doi:10.1016/S0968-0896(02)00524-2

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Daniele Passarella, Raffaele Favia, Alessandra Giardini, Giordano Lesma, Marisa Martinelli, Alessandra Silvani, Bruno Danieli, Simon M.N. Efange, Deborah C. Mash

Neurology

Research output: Contribution to journal › Article

23 Scopus citations

Abstract

Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

Original language	English (US)
Pages (from-to)	1007-1014
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0896(02)00524-2
State	Published - Mar 1 2003

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0968-0896(02)00524-2

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Passarella, D., Favia, R., Giardini, A., Lesma, G., Martinelli, M., Silvani, A., Danieli, B., Efange, S. M. N., & Mash, D. C. (2003). Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes. Bioorganic and Medicinal Chemistry, 11(6), 1007-1014. https://doi.org/10.1016/S0968-0896(02)00524-2

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes. / Passarella, Daniele; Favia, Raffaele; Giardini, Alessandra; Lesma, Giordano; Martinelli, Marisa; Silvani, Alessandra; Danieli, Bruno; Efange, Simon M.N.; Mash, Deborah C.

In: Bioorganic and Medicinal Chemistry, Vol. 11, No. 6, 01.03.2003, p. 1007-1014.

Research output: Contribution to journal › Article

Passarella, Daniele ; Favia, Raffaele ; Giardini, Alessandra ; Lesma, Giordano ; Martinelli, Marisa ; Silvani, Alessandra ; Danieli, Bruno ; Efange, Simon M.N. ; Mash, Deborah C. / Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes. In: Bioorganic and Medicinal Chemistry. 2003 ; Vol. 11, No. 6. pp. 1007-1014.

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