Abstract
Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.
Original language | English (US) |
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Pages (from-to) | 1007-1014 |
Number of pages | 8 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - Mar 1 2003 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry