Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Daniele Passarella, Raffaele Favia, Alessandra Giardini, Giordano Lesma, Marisa Martinelli, Alessandra Silvani, Bruno Danieli, Simon M.N. Efange, Deborah C. Mash

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

Original languageEnglish (US)
Pages (from-to)1007-1014
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume11
Issue number6
DOIs
StatePublished - Mar 1 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Passarella, D., Favia, R., Giardini, A., Lesma, G., Martinelli, M., Silvani, A., Danieli, B., Efange, S. M. N., & Mash, D. C. (2003). Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes. Bioorganic and Medicinal Chemistry, 11(6), 1007-1014. https://doi.org/10.1016/S0968-0896(02)00524-2