Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Daniele Passarella; Raffaele Favia; Alessandra Giardini; Giordano Lesma; Marisa Martinelli; Alessandra Silvani; Bruno Danieli; Simon M.N. Efange; Deborah C. Mash

doi:10.1016/S0968-0896(02)00524-2

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Daniele Passarella, Raffaele Favia, Alessandra Giardini, Giordano Lesma, Marisa Martinelli, Alessandra Silvani, Bruno Danieli, Simon M.N. Efange, Deborah C. Mash

Neurology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

Original language	English (US)
Pages (from-to)	1007-1014
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0896(02)00524-2
State	Published - Mar 2003

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0968-0896(02)00524-2

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Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes. / Passarella, Daniele; Favia, Raffaele; Giardini, Alessandra; Lesma, Giordano; Martinelli, Marisa; Silvani, Alessandra; Danieli, Bruno; Efange, Simon M.N.; Mash, Deborah C.

In: Bioorganic and Medicinal Chemistry, Vol. 11, No. 6, 03.2003, p. 1007-1014.

Research output: Contribution to journal › Article › peer-review

Passarella, Daniele ; Favia, Raffaele ; Giardini, Alessandra ; Lesma, Giordano ; Martinelli, Marisa ; Silvani, Alessandra ; Danieli, Bruno ; Efange, Simon M.N. ; Mash, Deborah C. / Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes. In: Bioorganic and Medicinal Chemistry. 2003 ; Vol. 11, No. 6. pp. 1007-1014.

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title = "Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes",

abstract = "Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.",

author = "Daniele Passarella and Raffaele Favia and Alessandra Giardini and Giordano Lesma and Marisa Martinelli and Alessandra Silvani and Bruno Danieli and Efange, {Simon M.N.} and Mash, {Deborah C.}",

note = "Funding Information: This work was supported by the Ministero dell'Istruzione dell'Universit{\`a} e della Ricerca (MIUR) (COFIN 2000: {\textquoteleft}Studio chimico e biologico di piante medicinali e alimentari di origine africana{\textquoteright}). ",

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doi = "10.1016/S0968-0896(02)00524-2",

language = "English (US)",

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AU - Passarella, Daniele

AU - Favia, Raffaele

AU - Giardini, Alessandra

AU - Lesma, Giordano

AU - Martinelli, Marisa

AU - Silvani, Alessandra

AU - Danieli, Bruno

AU - Efange, Simon M.N.

AU - Mash, Deborah C.

N1 - Funding Information: This work was supported by the Ministero dell'Istruzione dell'Università e della Ricerca (MIUR) (COFIN 2000: ‘Studio chimico e biologico di piante medicinali e alimentari di origine africana’).

PY - 2003/3

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N2 - Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

AB - Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

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Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Abstract

ASJC Scopus subject areas

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