Hysteroscopic metroplasty for T-shaped uterus: A Systematic Review and Meta-analysis of Reproductive Outcomes

Simone Garzon, Antonio Simone Laganà, Attilio Di Spiezio Sardo, Luis Alonso Pacheco, Sergio Haimovich, Jose Carugno, Salvatore Giovanni Vitale, Jvan Casarin, Ricciarda Raffaelli, Alessandra Andrisani, Brunella Zizolfi, Antonella Cromi, Fabio Ghezzi, Massimo Franchi, Amerigo Vitagliano

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Importance: To date, a comprehensive review on the safety and effectiveness of hysteroscopic metroplasty for T-shaped uterus is still missing. Objective: To provide a robust synthesis of the available studies investigating reproductive outcomes after hysteroscopic metroplasty for T-shaped uterus. Evidence Acquisition: We performed a systematic review and meta-analysis (CRD42019143291), using the proportion method with 95% confidence interval (CI). Statistical heterogeneity was assessed by Higgins test (I2). Results: We included 11 cohort studies embedding 937 women who underwent hysteroscopic metroplasty. After surgery, the pooled percentage of live birth was 44.54% (95% CI, 36.12%–53.12%; I2 = 46.22%) and 56.88% (95% CI, 46.48%–66.98%; I2 = 36.38%) in women with primary infertility and recurrent miscarriage, respectively. In women with recurrent miscarriage, the pooled proportion of miscarriage was 21.46% (95% CI, 15.09%–28.61%; I2 = 30.18%). The pooled clinical pregnancy proportion in women with primary infertility was 57.19% (95% CI, 43.83%–70.03%; I2 = 77.81%). The pooled rate of surgical complications was 0.65% (95% CI, 0.20%–1.33%; I2 = 11.44%). Conclusions: The hysteroscopic correction of T-shaped uteri was associated with high live birth rate and low miscarriage rate, both in case of primary infertility and recurrent miscarriage.

Original languageEnglish (US)
Pages (from-to)431-444
Number of pages14
JournalObstetrical and Gynecological Survey
Volume75
Issue number7
DOIs
StatePublished - Jul 1 2020

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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