Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor

Stephen L. Archer, Jonathan P. Tolins, Leopoldo Raij, E. Kenneth Weir

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Inhibition of the synthesis of endothelium derived relaxing factor by NG-monomethyl-L-arginine, a competitive inhibitor of the synthesis of nitric oxide from L-arginine, enhances hypoxic pulmonary vasoconstriction in pulmonary artery rings and isolated, Krebs albumin perfused rat lungs. L-arginine rapidly reduces hypoxic vasoconstriction, particularly in lungs treated with NG-monomethyl-L-arginine. Following administration of NG-monomethyl-L-arginine, bradykinin-induced vasodilation is inhibited (p<0.01) and a bradykinin-induced vasoconstriction develops (p<0.001). NG-monomethyl-L-arginine does not significantly diminish acetylcholine-induced vasodilatation in the isolated lung. NG-monomethyl-L-arginine causes an endothelium-dependent vasoconstriction in pulmonary artery rings.

Original languageEnglish
Pages (from-to)1198-1205
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume164
Issue number3
DOIs
StatePublished - Nov 15 1989
Externally publishedYes

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omega-N-Methylarginine
Endothelium-Dependent Relaxing Factors
Vasoconstriction
Lung
Bradykinin
Vasodilation
Pulmonary Artery
Arginine
Acetylcholine
Endothelium
Rats
Albumins
Nitric Oxide

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. / Archer, Stephen L.; Tolins, Jonathan P.; Raij, Leopoldo; Weir, E. Kenneth.

In: Biochemical and Biophysical Research Communications, Vol. 164, No. 3, 15.11.1989, p. 1198-1205.

Research output: Contribution to journalArticle

Archer, Stephen L. ; Tolins, Jonathan P. ; Raij, Leopoldo ; Weir, E. Kenneth. / Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. In: Biochemical and Biophysical Research Communications. 1989 ; Vol. 164, No. 3. pp. 1198-1205.
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