Hypoxia preadaptation prevents oxygen-induced depression of lung angiotensin-converting enzyme activity

R. M. Jackson, J. B. Pisarello

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Preadaptation of adult rats to hypoxia (10% O2 for 5 days) results in tolerance to oxygen-induced lung injury (> 95% O2 for 2 days). This study investigated whether hypoxia preadaptation maintained an endothelial cell metabolic function, angiotensin-converting enzyme (ACE) activity, despite exposure to hyperoxia. Lung ACE activity was measured as the capacity of isolated, ventilated, perfused lungs to hydrolyze an ACE substrate, benzoyl-phenylalanyl-alanyl-proline (BPAP), after in vivo hypoxia, hyperoxia, or sequential hypoxia-hyperoxia exposure. The results indicated that (1) hyperoxia decreases BPAP hydrolysis in isolated lungs, (2) hypoxia preadaptation does not affect BPAP hydrolysis [measured at ambient P(O2)], and (3) hypoxia preadaptation prevents hyperoxia-induced depression of lung ACE activity. These data imply that lung microvascular endothelial cells participate in the development of oxygen tolerance in this model.

Original languageEnglish (US)
Pages (from-to)424-428
Number of pages5
JournalAmerican Review of Respiratory Disease
Issue number3
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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