Abstract
A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, caused by activation of the melatonin receptor. These events result in the high and uncontrolled production of free radicals and toxic products of melanogenesis which sequentially damage or destroy melanocytes and keratinocytes, provoke an autoimmune response against exposed intracellular or altered cell surface antigenes, and increase the propensity of melanocytes to undergo malignant transformation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 539-541 |
| Number of pages | 3 |
| Journal | Journal of the Royal Society of Medicine |
| Volume | 82 |
| Issue number | 9 |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Hypothesis : Possible role for the melatonin receptor in vitiligo: Discussion paper. / Slominski, A.; Paus, Ralf; Bomirski, A.
In: Journal of the Royal Society of Medicine, Vol. 82, No. 9, 01.01.1989, p. 539-541.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypothesis
T2 - Possible role for the melatonin receptor in vitiligo: Discussion paper
AU - Slominski, A.
AU - Paus, Ralf
AU - Bomirski, A.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, caused by activation of the melatonin receptor. These events result in the high and uncontrolled production of free radicals and toxic products of melanogenesis which sequentially damage or destroy melanocytes and keratinocytes, provoke an autoimmune response against exposed intracellular or altered cell surface antigenes, and increase the propensity of melanocytes to undergo malignant transformation.
AB - A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, caused by activation of the melatonin receptor. These events result in the high and uncontrolled production of free radicals and toxic products of melanogenesis which sequentially damage or destroy melanocytes and keratinocytes, provoke an autoimmune response against exposed intracellular or altered cell surface antigenes, and increase the propensity of melanocytes to undergo malignant transformation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024395461&partnerID=8YFLogxK
M3 - Article
C2 - 2552111
AN - SCOPUS:0024395461
VL - 82
SP - 539
EP - 541
JO - Journal of the Royal Society of Medicine
JF - Journal of the Royal Society of Medicine
SN - 0141-0768
IS - 9
ER -