TY - JOUR
T1 - Hypothesis
T2 - Possible role for the melatonin receptor in vitiligo: Discussion paper
AU - Slominski, A.
AU - Paus, R.
AU - Bomirski, A.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, caused by activation of the melatonin receptor. These events result in the high and uncontrolled production of free radicals and toxic products of melanogenesis which sequentially damage or destroy melanocytes and keratinocytes, provoke an autoimmune response against exposed intracellular or altered cell surface antigenes, and increase the propensity of melanocytes to undergo malignant transformation.
AB - A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, caused by activation of the melatonin receptor. These events result in the high and uncontrolled production of free radicals and toxic products of melanogenesis which sequentially damage or destroy melanocytes and keratinocytes, provoke an autoimmune response against exposed intracellular or altered cell surface antigenes, and increase the propensity of melanocytes to undergo malignant transformation.
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U2 - 10.1177/014107688908200911
DO - 10.1177/014107688908200911
M3 - Article
C2 - 2552111
AN - SCOPUS:0024395461
VL - 82
SP - 539
EP - 541
JO - Journal of the Royal Society of Medicine
JF - Journal of the Royal Society of Medicine
SN - 0141-0768
IS - 9
ER -