Hypothermia as a clinical neuroprotectant

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Applying therapeutic hypothermia (TH) for the purposes of neuroprotection, originally termed "hibernation," started nearly 100 years ago. Because TH cooling systems have improved to the point where it is practical and safe for general application, interest in providing such treatment in conditions such as spinal cord injury, traumatic brain injury, stroke, and cardiac arrest has increased. This article reviews the mechanisms by which TH mitigates secondary neurologic injury, the clinical scenarios where TH is being applied, and reviews selected published studies using TH for central nervous system neuroprotection.

Original languageEnglish (US)
Pages (from-to)519-529
Number of pages11
JournalPhysical Medicine and Rehabilitation Clinics of North America
Issue number3
StatePublished - Aug 2014


  • ASIA score
  • Hypothermia
  • Methylprednisolone
  • Neuroprotection
  • Spinal cord injury
  • Trauma

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation


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