Recent studies on the hypothalamic hormones are reviewed. A decapeptide has recently been isolated from pig hypothalamus with the activity of an FSH and LH liberating hormone. The sequence of amino acids was established and the decapeptide corresponding to this structure was synthesized. The decapeptide stimulated the liberation of LH and FSH in experimental animals and man. Natural and synthetic LH RH/FSH RH also stimulated the synthesis of both gonadotropins in tissue cultures of rat hypophysis in vitro. It is postulated that this decapeptide is the hypothalamic hormone which controls the release of LH and FSH from the anterior pituitary. The effects of sex steroids on LH and FSH release are reviewed in brief. Superior control of FSH and LH secretion is probably mediated by the interaction of the hypothalamic hormone with sex steroids. Clinical studies of LH RH/FSH RH are reviewed. These studies, particularly those concerning the induction of ovulation, suggest that LH RH may have clinical applications in the treatment of sterility. Since LH RH is now synthesized by various laboratories, sufficient material is available for long term evaluation of these hormones. Comments are made on the probable clinical use of LH RH and on the possibility of developing new methods of birth control based on LH RH.
|Translated title of the contribution||Hypothalamus and fertility (Recent clinical and physiologic studies on natural and synthetic hypothalamic hormone releasing LH and FSH)|
|Number of pages||29|
|State||Published - Jan 1 1973|
ASJC Scopus subject areas
- Obstetrics and Gynecology