Hypothalamic releasing and inhibiting hormones

Andrew V. Schally, Abba J. Kastin

Research output: Contribution to journalArticle

6 Scopus citations


Distinct substances have been prepared from hypothalamic extracts of several species including man, which in minute amounts stimulate the release of thyrotropin, growth hormone, follicle-stimulating hormone and luteinizing hormone, and inhibit the release of prolactin and melanocyte-stimulating hormone. The structures of TRH, MIF, GH-RH, and LH-RH FSH-RH have been determined. Various physiological and biochemical studies indicate that these substances play an important physiological role as principal regulators of secretion of pituitary hormones. Clinical studies indicate that hypothalamic hormones may be of practical clinical significance in the diagnosis and treatment of disease.

Original languageEnglish (US)
Pages (from-to)76-85
Number of pages10
JournalGeneral and Comparative Endocrinology
Issue numberSUPPL.
StatePublished - 1972
Externally publishedYes


ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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