Distinct substances have been prepared from hypothalamic extracts of several species including man, which in minute amounts stimulate the release of thyrotropin, growth hormone, follicle-stimulating hormone and luteinizing hormone, and inhibit the release of prolactin and melanocyte-stimulating hormone. The structures of TRH, MIF, GH-RH, and LH-RH FSH-RH have been determined. Various physiological and biochemical studies indicate that these substances play an important physiological role as principal regulators of secretion of pituitary hormones. Clinical studies indicate that hypothalamic hormones may be of practical clinical significance in the diagnosis and treatment of disease.
ASJC Scopus subject areas
- Animal Science and Zoology