Hypothalamic regulation of FSH and LH secretion.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The regulation of pituitary gonadotropin secretion by the interactions between follicle stimulating hormone-releasing hormone (FSH-RH), luteinizing hormone-RH, and sex steroids is reviewed. Ovarian and testicular sex steroids act to block the further release of LH and FSH, stimulated by LH-RH and FSH-RH, presumably by suppressing the hypothalamic release of gonadotropin-releasing hormones. Studies have shown that receptor sites sensitive to the feedback effect of sex steroids exist primarily in the hypothalamus, though there is some evidence for their existence in the pituitary also. It is also possible that LH and FSH provide inhibitory impulses in a short-loop feedback system. LH-RH, in doses as small as .2 mcg, has been shown to induce a rapid increase in plasma LH. It has been suggested that 1 hypothalamic substance is responsible for the release of both FSH and LH. The stimulatory effect of LH-RH is not blocked by the administration of estrogen-progestogen oral contraceptives (OCs), which suggests that OCs, as well as clomiphene, act principally on the hypothalamus rather than the pituitary. High doses of clomiphene may block FSH and LH release, whereas low doses appear to stimulate their release. It appears that the structure of LH-RH resembles those of thyrotropin-releasing hormone and growth hormone-releasing hormone. Various approaches to fertility control utilizing synthetic LH-RH are discussed.

Original languageEnglish
Pages (from-to)2-3
Number of pages2
JournalResearch in reproduction
Volume2
Issue number4
StatePublished - Jul 1 1970
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Clomiphene
Steroids
Follicle Stimulating Hormone
Oral Contraceptives
Hypothalamus
Pituitary Gonadotropins
Growth Hormone-Releasing Hormone
Thyrotropin-Releasing Hormone
Progestins
Contraception
Estrogens
Hormones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypothalamic regulation of FSH and LH secretion. / Schally, Andrew V.

In: Research in reproduction, Vol. 2, No. 4, 01.07.1970, p. 2-3.

Research output: Contribution to journalArticle

@article{3b5ec80cc4904766b81167498f448569,
title = "Hypothalamic regulation of FSH and LH secretion.",
abstract = "The regulation of pituitary gonadotropin secretion by the interactions between follicle stimulating hormone-releasing hormone (FSH-RH), luteinizing hormone-RH, and sex steroids is reviewed. Ovarian and testicular sex steroids act to block the further release of LH and FSH, stimulated by LH-RH and FSH-RH, presumably by suppressing the hypothalamic release of gonadotropin-releasing hormones. Studies have shown that receptor sites sensitive to the feedback effect of sex steroids exist primarily in the hypothalamus, though there is some evidence for their existence in the pituitary also. It is also possible that LH and FSH provide inhibitory impulses in a short-loop feedback system. LH-RH, in doses as small as .2 mcg, has been shown to induce a rapid increase in plasma LH. It has been suggested that 1 hypothalamic substance is responsible for the release of both FSH and LH. The stimulatory effect of LH-RH is not blocked by the administration of estrogen-progestogen oral contraceptives (OCs), which suggests that OCs, as well as clomiphene, act principally on the hypothalamus rather than the pituitary. High doses of clomiphene may block FSH and LH release, whereas low doses appear to stimulate their release. It appears that the structure of LH-RH resembles those of thyrotropin-releasing hormone and growth hormone-releasing hormone. Various approaches to fertility control utilizing synthetic LH-RH are discussed.",
author = "Schally, {Andrew V}",
year = "1970",
month = "7",
day = "1",
language = "English",
volume = "2",
pages = "2--3",
journal = "Research in reproduction",
issn = "0034-5253",
number = "4",

}

TY - JOUR

T1 - Hypothalamic regulation of FSH and LH secretion.

AU - Schally, Andrew V

PY - 1970/7/1

Y1 - 1970/7/1

N2 - The regulation of pituitary gonadotropin secretion by the interactions between follicle stimulating hormone-releasing hormone (FSH-RH), luteinizing hormone-RH, and sex steroids is reviewed. Ovarian and testicular sex steroids act to block the further release of LH and FSH, stimulated by LH-RH and FSH-RH, presumably by suppressing the hypothalamic release of gonadotropin-releasing hormones. Studies have shown that receptor sites sensitive to the feedback effect of sex steroids exist primarily in the hypothalamus, though there is some evidence for their existence in the pituitary also. It is also possible that LH and FSH provide inhibitory impulses in a short-loop feedback system. LH-RH, in doses as small as .2 mcg, has been shown to induce a rapid increase in plasma LH. It has been suggested that 1 hypothalamic substance is responsible for the release of both FSH and LH. The stimulatory effect of LH-RH is not blocked by the administration of estrogen-progestogen oral contraceptives (OCs), which suggests that OCs, as well as clomiphene, act principally on the hypothalamus rather than the pituitary. High doses of clomiphene may block FSH and LH release, whereas low doses appear to stimulate their release. It appears that the structure of LH-RH resembles those of thyrotropin-releasing hormone and growth hormone-releasing hormone. Various approaches to fertility control utilizing synthetic LH-RH are discussed.

AB - The regulation of pituitary gonadotropin secretion by the interactions between follicle stimulating hormone-releasing hormone (FSH-RH), luteinizing hormone-RH, and sex steroids is reviewed. Ovarian and testicular sex steroids act to block the further release of LH and FSH, stimulated by LH-RH and FSH-RH, presumably by suppressing the hypothalamic release of gonadotropin-releasing hormones. Studies have shown that receptor sites sensitive to the feedback effect of sex steroids exist primarily in the hypothalamus, though there is some evidence for their existence in the pituitary also. It is also possible that LH and FSH provide inhibitory impulses in a short-loop feedback system. LH-RH, in doses as small as .2 mcg, has been shown to induce a rapid increase in plasma LH. It has been suggested that 1 hypothalamic substance is responsible for the release of both FSH and LH. The stimulatory effect of LH-RH is not blocked by the administration of estrogen-progestogen oral contraceptives (OCs), which suggests that OCs, as well as clomiphene, act principally on the hypothalamus rather than the pituitary. High doses of clomiphene may block FSH and LH release, whereas low doses appear to stimulate their release. It appears that the structure of LH-RH resembles those of thyrotropin-releasing hormone and growth hormone-releasing hormone. Various approaches to fertility control utilizing synthetic LH-RH are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0014808291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014808291&partnerID=8YFLogxK

M3 - Article

C2 - 12254980

AN - SCOPUS:0014808291

VL - 2

SP - 2

EP - 3

JO - Research in reproduction

JF - Research in reproduction

SN - 0034-5253

IS - 4

ER -