Hypothalamic, midbrain and bulbar areas involved in the defense reaction in rabbits

Carrie G. Markgraf, Ray Winters, David R. Liskowsky, Philip McCabe, Edward J. Green, Neil Schneiderman

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The present study mapped neuroanatomical sites in the hypothalamus and periaqueductal gray (PAG) of the rabbit which, when stimulated electrically, evoked the cardiorespiratory components of the defense reaction (CRDR). This included increases in heart rate, blood pressure, hindlimb blood flow and respiration rate. All of the components of the CRDR were elicited by electrical stimulation of the posterior hypothalamus, at sites dorsal and medial to the fornix. Although there were regions throughout the PAG in which electrical stimulation elicited concomitant increases in blood pressure, hindlimb blood flow and respiration rate, only stimulation of the dorsal PAG evoked tachycardia. Injection of horseradish peroxidase into the rostral ventrolateral medulla (RVLM) led to heavy retrograde and anterograde labeling in the region of the hypothalamus that yielded the CRDR when stimulated electrically. Heavy labeling was also observed in the dorsal and ventral PAG. The results of this study provide evidence that the posterior hypothalamus and the dorsal PAG are nodal structures in the mediation of the CRDR and that cells in posterior hypothalamus, dorsal PAG and ventral PAG make monosynaptic connections with the RVLM.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalPhysiology and Behavior
Volume49
Issue number3
DOIs
StatePublished - Jan 1 1991

Fingerprint

Periaqueductal Gray
Mesencephalon
Rabbits
Posterior Hypothalamus
Hindlimb
Respiratory Rate
Electric Stimulation
Hypothalamus
Blood Pressure
Horseradish Peroxidase
Tachycardia
Heart Rate
Injections

Keywords

  • Defense reaction
  • Hypothalamus
  • Periaqueductal gray
  • Rostral ventrolateral medulla

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Hypothalamic, midbrain and bulbar areas involved in the defense reaction in rabbits. / Markgraf, Carrie G.; Winters, Ray; Liskowsky, David R.; McCabe, Philip; Green, Edward J.; Schneiderman, Neil.

In: Physiology and Behavior, Vol. 49, No. 3, 01.01.1991, p. 493-500.

Research output: Contribution to journalArticle

Markgraf, Carrie G. ; Winters, Ray ; Liskowsky, David R. ; McCabe, Philip ; Green, Edward J. ; Schneiderman, Neil. / Hypothalamic, midbrain and bulbar areas involved in the defense reaction in rabbits. In: Physiology and Behavior. 1991 ; Vol. 49, No. 3. pp. 493-500.
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