Hypothalamic hormones: From neuroendocrinology to cancer therapy

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

The discovery of hypothalamic hormones, especially LH-RH and somatostatin has led to practical clinical use of their analogs in the field of cancer treatment. Bombesin/GRP antagonists can be also considered for the development of new methods for treatment of various tumors. The understanding of functions of these peptide hormones and the availability of their synthetic analogs should permit the clinicians to treat a variety of cancers more successfully than in the past.

Original languageEnglish (US)
Pages (from-to)115-130
Number of pages16
JournalAnti-Cancer Drugs
Volume5
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • antitumor activity
  • bombesin/gastrin releasing peptide
  • corticotropin-releasing factor
  • cytotoxic peptide analogs
  • luteinizing hormone-releasing hormone
  • somatostatin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

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