Hypothalamic hormones: From neuroendocrinology to cancer therapy

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


The discovery of hypothalamic hormones, especially LH-RH and somatostatin has led to practical clinical use of their analogs in the field of cancer treatment. Bombesin/GRP antagonists can be also considered for the development of new methods for treatment of various tumors. The understanding of functions of these peptide hormones and the availability of their synthetic analogs should permit the clinicians to treat a variety of cancers more successfully than in the past.

Original languageEnglish (US)
Pages (from-to)115-130
Number of pages16
JournalAnti-Cancer Drugs
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes


  • antitumor activity
  • bombesin/gastrin releasing peptide
  • corticotropin-releasing factor
  • cytotoxic peptide analogs
  • luteinizing hormone-releasing hormone
  • somatostatin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology


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