HYPOTHALAMIC HORMONE INTERACTION IN ACROMEGALY

A. GOMEZ‐PAN, W. M.G. TUNBRIDGE, ANNE DUNS, R. HALL, G. M. BESSER, D. H. COY, A. V. SCHALLY, A. J. KASTIN

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in 11 patients with acromegaly. Eight of them showed a positive GH response to thyrotrophin releasing hormone and 3 showed no response. The GH response to TRH was shown to be unrelated to the thyrotrophin response to TRH. The GH response to TRH was inhibited by the administration of growth hormone release inhibiting hormone. Luteinizing hormone/follicle stimulating hormone releasing hormone (LHRH) caused a positive GH response in four patients, but this was trivial in three. The TRH mediated GH release in acromegaly is not mediated via TSH and appears to be attributable to loss of specificity of the receptor sites on the somatotroph to the hypothalamic hormones.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
JournalClinical Endocrinology
Volume4
Issue number5
DOIs
StatePublished - Sep 1975
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    GOMEZ‐PAN, A., TUNBRIDGE, W. M. G., DUNS, ANNE., HALL, R., BESSER, G. M., COY, D. H., SCHALLY, A. V., & KASTIN, A. J. (1975). HYPOTHALAMIC HORMONE INTERACTION IN ACROMEGALY. Clinical Endocrinology, 4(5), 455-460. https://doi.org/10.1111/j.1365-2265.1975.tb01554.x