Abstract
The growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in 11 patients with acromegaly. Eight of them showed a positive GH response to thyrotrophin releasing hormone and 3 showed no response. The GH response to TRH was shown to be unrelated to the thyrotrophin response to TRH. The GH response to TRH was inhibited by the administration of growth hormone release inhibiting hormone. Luteinizing hormone/follicle stimulating hormone releasing hormone (LHRH) caused a positive GH response in four patients, but this was trivial in three. The TRH mediated GH release in acromegaly is not mediated via TSH and appears to be attributable to loss of specificity of the receptor sites on the somatotroph to the hypothalamic hormones.
| Original language | English |
|---|---|
| Pages (from-to) | 455-460 |
| Number of pages | 6 |
| Journal | Clinical Endocrinology |
| Volume | 4 |
| Issue number | 5 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Hypothalamic hormone interaction in acromegaly. / Gomez Pan, A.; Tunbridge, W. M G; Duns, A.; Hall, R.; Besser, G. M.; Coy, D. H.; Schally, Andrew V; Kastin, A. J.
In: Clinical Endocrinology, Vol. 4, No. 5, 01.12.1975, p. 455-460.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypothalamic hormone interaction in acromegaly
AU - Gomez Pan, A.
AU - Tunbridge, W. M G
AU - Duns, A.
AU - Hall, R.
AU - Besser, G. M.
AU - Coy, D. H.
AU - Schally, Andrew V
AU - Kastin, A. J.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - The growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in 11 patients with acromegaly. Eight of them showed a positive GH response to thyrotrophin releasing hormone and 3 showed no response. The GH response to TRH was shown to be unrelated to the thyrotrophin response to TRH. The GH response to TRH was inhibited by the administration of growth hormone release inhibiting hormone. Luteinizing hormone/follicle stimulating hormone releasing hormone (LHRH) caused a positive GH response in four patients, but this was trivial in three. The TRH mediated GH release in acromegaly is not mediated via TSH and appears to be attributable to loss of specificity of the receptor sites on the somatotroph to the hypothalamic hormones.
AB - The growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in 11 patients with acromegaly. Eight of them showed a positive GH response to thyrotrophin releasing hormone and 3 showed no response. The GH response to TRH was shown to be unrelated to the thyrotrophin response to TRH. The GH response to TRH was inhibited by the administration of growth hormone release inhibiting hormone. Luteinizing hormone/follicle stimulating hormone releasing hormone (LHRH) caused a positive GH response in four patients, but this was trivial in three. The TRH mediated GH release in acromegaly is not mediated via TSH and appears to be attributable to loss of specificity of the receptor sites on the somatotroph to the hypothalamic hormones.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016802768&partnerID=8YFLogxK
M3 - Article
C2 - 170027
AN - SCOPUS:0016802768
VL - 4
SP - 455
EP - 460
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 5
ER -