CONTROL HIPOTALAMICO DE LA FUNCION HIPOFISARIA! CON ESPECIAL REFERENCIA A LA REPRODUCCION. ESTUDIOS CLINICOS Y EXPERIMENTALES

Translated title of the contribution: Hypothalamic control of pituitary function, with special reference to reproduction. Clinical and experimental studies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The latest physiological and biochemical findings concerning the hypothalamic hormones involved in the release of thyrotropin, prolactin and growth hormone, and the inhibitor of melanocyte stimulating hormone (MSH) and prolactin release are reviewed. The clinical studies made, suggest that at least thyrotropin releasing hormone (TRH) can be of significantly practical clinical use in diagnosis. The latest in the field of those hypothalamic hormones controlling LH and FSH release are also reviewed. Recently, the author succeeded in isolating an LH and FSH releasing decapeptide from porcine hypothalamus. Later, this decapeptide has been synthesized, and its administration stimulates LH and FSH release in domestic and laboratory animals, and in man. Natural and synthetic luteinizing hormone releasing hormone (LH-RH) also stimulates LH and FSH biosynthesis in rat pituitary tissue cultures in vitro. The author claims that this decapeptide is no other than the hypothalamic hormone which regulates LH and FSH release. He also believes that the control of LH and FSH secretion is almost probably influenced by the interaction between LH and FSH releasing hormone and sexual steroids. From the specific point of view of therapy, LH-RH appears to be the most important of all releasing hormones of hypothalamic origin. This substance, relatively simple in its composition, offers a wide spectrum of perspectives in the field of fertility stimulation in animals and in man. Because of its ovulation inductive properties, it is suggested that it could be used in the clinical treatment of sterility. Future findings on the properties of this hormone, or its various derivates, could lead to new methods in birth control.

Original languageSpanish
Title of host publicationACTA MED.TENERIFE
Pages193-212
Number of pages20
Volume34
Edition3
StatePublished - Dec 1 1973
Externally publishedYes

Fingerprint

Hypothalamic Hormones
Gonadotropin-Releasing Hormone
Reproduction
Prolactin
Pituitary Hormone-Releasing Hormones
Melanocyte-Stimulating Hormones
Growth Inhibitors
Thyrotropin-Releasing Hormone
Domestic Animals
Laboratory Animals
Thyrotropin
Ovulation
Contraception
Infertility
Growth Hormone
Hypothalamus
Fertility
Swine
Steroids
Hormones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

CONTROL HIPOTALAMICO DE LA FUNCION HIPOFISARIA! CON ESPECIAL REFERENCIA A LA REPRODUCCION. ESTUDIOS CLINICOS Y EXPERIMENTALES. / Schally, Andrew V.

ACTA MED.TENERIFE. Vol. 34 3. ed. 1973. p. 193-212.

Research output: Chapter in Book/Report/Conference proceedingChapter

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abstract = "The latest physiological and biochemical findings concerning the hypothalamic hormones involved in the release of thyrotropin, prolactin and growth hormone, and the inhibitor of melanocyte stimulating hormone (MSH) and prolactin release are reviewed. The clinical studies made, suggest that at least thyrotropin releasing hormone (TRH) can be of significantly practical clinical use in diagnosis. The latest in the field of those hypothalamic hormones controlling LH and FSH release are also reviewed. Recently, the author succeeded in isolating an LH and FSH releasing decapeptide from porcine hypothalamus. Later, this decapeptide has been synthesized, and its administration stimulates LH and FSH release in domestic and laboratory animals, and in man. Natural and synthetic luteinizing hormone releasing hormone (LH-RH) also stimulates LH and FSH biosynthesis in rat pituitary tissue cultures in vitro. The author claims that this decapeptide is no other than the hypothalamic hormone which regulates LH and FSH release. He also believes that the control of LH and FSH secretion is almost probably influenced by the interaction between LH and FSH releasing hormone and sexual steroids. From the specific point of view of therapy, LH-RH appears to be the most important of all releasing hormones of hypothalamic origin. This substance, relatively simple in its composition, offers a wide spectrum of perspectives in the field of fertility stimulation in animals and in man. Because of its ovulation inductive properties, it is suggested that it could be used in the clinical treatment of sterility. Future findings on the properties of this hormone, or its various derivates, could lead to new methods in birth control.",
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