The latest physiological and biochemical findings concerning the hypothalamic hormones involved in the release of thyrotropin, prolactin and growth hormone, and the inhibitor of melanocyte stimulating hormone (MSH) and prolactin release are reviewed. The clinical studies made, suggest that at least thyrotropin releasing hormone (TRH) can be of significantly practical clinical use in diagnosis. The latest in the field of those hypothalamic hormones controlling LH and FSH release are also reviewed. Recently, the author succeeded in isolating an LH and FSH releasing decapeptide from porcine hypothalamus. Later, this decapeptide has been synthesized, and its administration stimulates LH and FSH release in domestic and laboratory animals, and in man. Natural and synthetic luteinizing hormone releasing hormone (LH-RH) also stimulates LH and FSH biosynthesis in rat pituitary tissue cultures in vitro. The author claims that this decapeptide is no other than the hypothalamic hormone which regulates LH and FSH release. He also believes that the control of LH and FSH secretion is almost probably influenced by the interaction between LH and FSH releasing hormone and sexual steroids. From the specific point of view of therapy, LH-RH appears to be the most important of all releasing hormones of hypothalamic origin. This substance, relatively simple in its composition, offers a wide spectrum of perspectives in the field of fertility stimulation in animals and in man. Because of its ovulation inductive properties, it is suggested that it could be used in the clinical treatment of sterility. Future findings on the properties of this hormone, or its various derivates, could lead to new methods in birth control.
|Translated title of the contribution||Hypothalamic control of pituitary function, with special reference to reproduction. Clinical and experimental studies|
|Title of host publication||ACTA MED.TENERIFE|
|Number of pages||20|
|State||Published - Dec 1 1973|
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