Hyposensitizing therapy with standard antigenic extracts: an important source of thimerosal sensitization

A. Tosti, L. Guerra, F. Bardazzi

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The frequency of thimerosal sensitization was determined in 5 groups of subjects: military recruits; healthy subjects; patients with asthma or rhinitis undergoing hyposensitizing therapy with thimerosal-preserved antigenic extracts; patients with allergic contact dermatitis; patient with allergic contact conjunctivitis. Our patients with allergic contact dermatitis have a higher incidence of positive patch tests to thimerosal than healthy subjects. The source of thimerosal sensitization in this group remains obscure, their history of exposure to this or to other mercury derivatives being comparable to that of the healthy population. Patients with allergic contact conjunctivitis and patients receiving immunotherapy for asthma or rhinitis present a significantly higher frequency of thimerosal sensitization than the other groups, indicating that ophthalmic solutions and thimerosal-preserved allergen extracts are an important source of thimerosal sensitization. The clinical relevance of thimerosal sensitization was definitively established only in patients with allergic contact conjunctivitis, even though patients receiving immunotherapy frequently presented local reactions at the site of allergen inoculation.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalContact dermatitis
Volume20
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

Keywords

  • allergen extracts
  • medicaments
  • mercury
  • ophthalmic solutions
  • thimerosal
  • vaccines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology

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