TY - JOUR
T1 - Hypoalgesia induced by the local injection of phentolamine in the nucleus raphe magnus
T2 - Blockade by depletion of spinal cord monoamines
AU - Sagen, J.
AU - Winker, M. A.
AU - Proudfit, H. K.
N1 - Funding Information:
This work was supported by Grant NS 18636 from the National Institutes of Health, United States Public Health Service and by a Predoctoral Fellowship from the Pharmaceutical Manufacturers Association.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1983/7
Y1 - 1983/7
N2 - Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of α-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spinal cord serotonin, norepinephrine, or both also blocks this hypoalgesia. Together these studies suggest that the hypoalgesia produced by microinjection of noradrenergic antagonists in the NRM is mediated by the activation of both raphe-spinal serotonergic neurons and bulbospinal noradrenergic neurons.
AB - Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of α-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spinal cord serotonin, norepinephrine, or both also blocks this hypoalgesia. Together these studies suggest that the hypoalgesia produced by microinjection of noradrenergic antagonists in the NRM is mediated by the activation of both raphe-spinal serotonergic neurons and bulbospinal noradrenergic neurons.
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U2 - 10.1016/0304-3959(83)90113-6
DO - 10.1016/0304-3959(83)90113-6
M3 - Article
C2 - 6310470
AN - SCOPUS:0020640975
VL - 16
SP - 253
EP - 263
JO - Pain
JF - Pain
SN - 0304-3959
IS - 3
ER -