Hypnotic efficacy of a modified triazolodiazepine, brotizolam

Roberto A. Dominguez, Burton J. Goldstein, Alan F. Jacobson, Richard M. Steinbook

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Fifty-nine outpatients with insomnia were treated in a 3-week study to assess the safety and efficacy of a new triazolothienodiazepine with a short t 1 2, brotizolam. Therapy was initiated with 0.25 mg at night, but by the end of the study all subjects who were receiving brotizolam were taking 0.50 mg. Results indicate brotizolam efficacy as measured by daily subject and weekly physician questionnaires in essentially all sleep parameters, including global subject and physician evaluation of treatment efficacy, sleep latency and sleep maintenance, and quality of sleep. Tolerance to the hypnotic action of brotizolam was not observed after 21 days of daily dosing.

Original languageEnglish (US)
Pages (from-to)674-679
Number of pages6
JournalClinical Pharmacology and Therapeutics
Issue number6
StatePublished - Jun 1985
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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