Hyperthyroidism and mitral-valve prolapse

B. J. Channick, E. V. Adlin, A. D. Marks, B. S. Denenberg, M. T. McDonough, C. S. Chakko, J. F. Spann

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79 Scopus citations


The authors looked for mitral-valve prolapse in 40 patients with hyperthyroidism, either previously treated or active at the time of study. Forty-three per cent of these patients had mitral-valve prolapse on the basis of cardiac ausculation and echocardiography. This figure was significantly higher than the 18 per cent prevalence in a control group matched for age, sex, and race. The prevalence of mitral-valve prolapse did not differ between those who had a history of hyperthyroidism and those who were currently hyperparathyroid. Palpitations, tachycardia, and other cardiac arrhythmias, with nervousness and anxiety, may be manifestations of mitral-valve prolapse as well as of hyperthyroidism. Mistakenly attributing these symptoms to the activity of the thyroid disease rather than to mitral-valve prolapse may lead to unnecessary testing for hyperthyroidism and possibly to inappropriate treatment. Since prophylactic antibiotic treatment is recommended for patients with mitral-valve prolapse at the time of dental or surgical procedures, physicians should look carefully for this cardiac abnormality in patients with a history of hyperthyroidism.

Original languageEnglish
Pages (from-to)497-500
Number of pages4
JournalNew England Journal of Medicine
Issue number9
StatePublished - Dec 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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