Hyperthyroidism and mitral-valve prolapse

B. J. Channick, E. V. Adlin, A. D. Marks, B. S. Denenberg, M. T. McDonough, C. S. Chakko, J. F. Spann

Research output: Contribution to journalArticle

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Abstract

The authors looked for mitral-valve prolapse in 40 patients with hyperthyroidism, either previously treated or active at the time of study. Forty-three per cent of these patients had mitral-valve prolapse on the basis of cardiac ausculation and echocardiography. This figure was significantly higher than the 18 per cent prevalence in a control group matched for age, sex, and race. The prevalence of mitral-valve prolapse did not differ between those who had a history of hyperthyroidism and those who were currently hyperparathyroid. Palpitations, tachycardia, and other cardiac arrhythmias, with nervousness and anxiety, may be manifestations of mitral-valve prolapse as well as of hyperthyroidism. Mistakenly attributing these symptoms to the activity of the thyroid disease rather than to mitral-valve prolapse may lead to unnecessary testing for hyperthyroidism and possibly to inappropriate treatment. Since prophylactic antibiotic treatment is recommended for patients with mitral-valve prolapse at the time of dental or surgical procedures, physicians should look carefully for this cardiac abnormality in patients with a history of hyperthyroidism.

Original languageEnglish
Pages (from-to)497-500
Number of pages4
JournalNew England Journal of Medicine
Volume305
Issue number9
StatePublished - Dec 1 1981
Externally publishedYes

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Mitral Valve Prolapse
Hyperthyroidism
Anxiety
Time and Motion Studies
Thyroid Diseases
Tachycardia
Echocardiography
Cardiac Arrhythmias
Tooth
Anti-Bacterial Agents
Physicians
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Channick, B. J., Adlin, E. V., Marks, A. D., Denenberg, B. S., McDonough, M. T., Chakko, C. S., & Spann, J. F. (1981). Hyperthyroidism and mitral-valve prolapse. New England Journal of Medicine, 305(9), 497-500.

Hyperthyroidism and mitral-valve prolapse. / Channick, B. J.; Adlin, E. V.; Marks, A. D.; Denenberg, B. S.; McDonough, M. T.; Chakko, C. S.; Spann, J. F.

In: New England Journal of Medicine, Vol. 305, No. 9, 01.12.1981, p. 497-500.

Research output: Contribution to journalArticle

Channick, BJ, Adlin, EV, Marks, AD, Denenberg, BS, McDonough, MT, Chakko, CS & Spann, JF 1981, 'Hyperthyroidism and mitral-valve prolapse', New England Journal of Medicine, vol. 305, no. 9, pp. 497-500.
Channick BJ, Adlin EV, Marks AD, Denenberg BS, McDonough MT, Chakko CS et al. Hyperthyroidism and mitral-valve prolapse. New England Journal of Medicine. 1981 Dec 1;305(9):497-500.
Channick, B. J. ; Adlin, E. V. ; Marks, A. D. ; Denenberg, B. S. ; McDonough, M. T. ; Chakko, C. S. ; Spann, J. F. / Hyperthyroidism and mitral-valve prolapse. In: New England Journal of Medicine. 1981 ; Vol. 305, No. 9. pp. 497-500.
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