Hypertension a risk factor for age-related macular degeneration: Role of angiotensin II

Maria E. Marin-Castaño

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The goal of this chapter is to review the most relevant scientific evidence supporting the role of Angiotensin II (Ang II), the major hormone associated with hypertension, in the pathogenesis of dry age-related macular degeneration (AMD), a leading cause of blindness among the elderly and to highlight the importance of hypertension treatment to reduce the risk for developing AMD. AMD is a late onset (after age 50), progressive degeneration of the retina associated with vision loss coupled with a spectrum of specific clinical, physiological and histopathological features. The early or dry stage of AMD is characterized by the accumulation of drusen, specific lipid rich deposits under the retina whereas the late or wet stage is characterized by growth of abnormal new vessels under the retinal pigment epithelium (RPE) from the subjacent choroid, termed choroidal neovascularization (CNV). Extracellular matrix turnover (ECM) and inflammation are key cellular processes that play a central role in the pathogenesis of AMD. The scientific evidence to support the proposed role of Ang II-mediated RPE effects on subretinal deposits formation and inflammation is reviewed in depth.

Original languageEnglish (US)
Title of host publicationAngiotensin
Subtitle of host publicationNew Research
PublisherNova Science Publishers, Inc.
Pages215-271
Number of pages57
ISBN (Print)9781621007739
StatePublished - Jan 1 2012

Keywords

  • Age-related macular degeneration
  • Angiotensin II
  • Angiotensin II receptors
  • Animal model.
  • Blebbing
  • Extracellular matrix turnover
  • Hypertension
  • Inflammation
  • Response to injury
  • Sub-RPE deposits
  • System renin-angiotensin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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