Hypersomnia with simultaneous waking and sleep patterns in the electroencephalogram - A case report with neurotransmitter studies

E. Niedermeyer, H. S. Singer, S. E. Folstein, R. P. Allen, F. Miranda, F. Fineyre, B. L. Bird

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A mildly dyslexic boy of 11 years, with no neurological deficit or history of epileptic seizures, had marked hypersomnia for 2 years, which was most pronounced in the morning hours. Repeated EEG studies and power spectral analysis revealed simultaneous posterior alpha rhythm and sleep patterns (spindles, vertex waves, K complexes) over vertex and frontocentral regions, while the patient was behaviorally awake. Bilateral synchronous anterior spikes were frequently noted in association with sleep patterns. A polysomnogram over 24h confirmed excessive sleep, night and day (especially morning hours) and there was evidence of a large REM sleep percentage (on EMG and EOG basis) while the EEG had predominantly non-REM sleep patterns. Special neurotransmitter studies were performed in view of a presumed disturbance affecting the neurobiochemical sleep regulation. These studies were based on CSF metabolite levels and provided evidence for a high serotonin metabolite (5HIAA) level. It is tempting to hypothesize that the biochemical disturbance has led to encroachment of non-REM sleep patterns on both wakefulness and REM sleep. Further discussion deals with the bilateral-synchronous spike activity and its relationship to arousal patterns in sleep.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalJournal of Neurology
Volume221
Issue number1
DOIs
StatePublished - Mar 1 1979

Keywords

  • EEG (sleep patterns)
  • Neurotransmitters
  • Sleep disorder
  • Sleep regulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Hypersomnia with simultaneous waking and sleep patterns in the electroencephalogram - A case report with neurotransmitter studies'. Together they form a unique fingerprint.

  • Cite this

    Niedermeyer, E., Singer, H. S., Folstein, S. E., Allen, R. P., Miranda, F., Fineyre, F., & Bird, B. L. (1979). Hypersomnia with simultaneous waking and sleep patterns in the electroencephalogram - A case report with neurotransmitter studies. Journal of Neurology, 221(1), 1-13. https://doi.org/10.1007/BF00313165