Abstract
Chronic lower extremity wounds include ulceration of the leg and foot. The underlying pathology that causes these conditions includes venous insufficiency, arterial disease, diabetes, and other less common disorders. Since the introduction of the homocysteine theory more than 30 years ago, considerable evidence has demonstrated hyperhomocysteinemia to be an independent risk factor for venous and arterial thrombosis, atherosclerosis and cardiovascular disease. Although any cause-effect relationship remains to be determined, hyperhomocysteinemia as a risk factor for these events suggests that elevated levels of homocysteine may also be a marker of chronic lower limb ulceration. This review addresses the metabolism of homocysteine, mechanisms of vascular injury, a role for hyperhomocysteinemia in lower extremity wounds and possible means of treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 126-136 |
| Number of pages | 11 |
| Journal | International Journal of Lower Extremity Wounds |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2008 |
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Keywords
- Folic acid
- Foot ulcer
- Hyperhomocysteinemia
- Leg ulcer
- Venous insufficiency
- Vitamin B12
ASJC Scopus subject areas
- Surgery
- Physical Therapy, Sports Therapy and Rehabilitation
- Dermatology
Cite this
Hyperhomocysteinemia and lower extremity wounds. / Schwartzfarb, Elissa M.; Romanelli, Paolo.
In: International Journal of Lower Extremity Wounds, Vol. 7, No. 3, 01.09.2008, p. 126-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hyperhomocysteinemia and lower extremity wounds
AU - Schwartzfarb, Elissa M.
AU - Romanelli, Paolo
PY - 2008/9/1
Y1 - 2008/9/1
N2 - Chronic lower extremity wounds include ulceration of the leg and foot. The underlying pathology that causes these conditions includes venous insufficiency, arterial disease, diabetes, and other less common disorders. Since the introduction of the homocysteine theory more than 30 years ago, considerable evidence has demonstrated hyperhomocysteinemia to be an independent risk factor for venous and arterial thrombosis, atherosclerosis and cardiovascular disease. Although any cause-effect relationship remains to be determined, hyperhomocysteinemia as a risk factor for these events suggests that elevated levels of homocysteine may also be a marker of chronic lower limb ulceration. This review addresses the metabolism of homocysteine, mechanisms of vascular injury, a role for hyperhomocysteinemia in lower extremity wounds and possible means of treatment.
AB - Chronic lower extremity wounds include ulceration of the leg and foot. The underlying pathology that causes these conditions includes venous insufficiency, arterial disease, diabetes, and other less common disorders. Since the introduction of the homocysteine theory more than 30 years ago, considerable evidence has demonstrated hyperhomocysteinemia to be an independent risk factor for venous and arterial thrombosis, atherosclerosis and cardiovascular disease. Although any cause-effect relationship remains to be determined, hyperhomocysteinemia as a risk factor for these events suggests that elevated levels of homocysteine may also be a marker of chronic lower limb ulceration. This review addresses the metabolism of homocysteine, mechanisms of vascular injury, a role for hyperhomocysteinemia in lower extremity wounds and possible means of treatment.
KW - Folic acid
KW - Foot ulcer
KW - Hyperhomocysteinemia
KW - Leg ulcer
KW - Venous insufficiency
KW - Vitamin B12
UR - http://www.scopus.com/inward/record.url?scp=49749131184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49749131184&partnerID=8YFLogxK
U2 - 10.1177/1534734608322490
DO - 10.1177/1534734608322490
M3 - Article
C2 - 18757388
AN - SCOPUS:49749131184
VL - 7
SP - 126
EP - 136
JO - International Journal of Lower Extremity Wounds
JF - International Journal of Lower Extremity Wounds
SN - 1534-7346
IS - 3
ER -