Hyperhomocysteinemia and lower extremity wounds

Elissa M. Schwartzfarb, Paolo Romanelli

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Chronic lower extremity wounds include ulceration of the leg and foot. The underlying pathology that causes these conditions includes venous insufficiency, arterial disease, diabetes, and other less common disorders. Since the introduction of the homocysteine theory more than 30 years ago, considerable evidence has demonstrated hyperhomocysteinemia to be an independent risk factor for venous and arterial thrombosis, atherosclerosis and cardiovascular disease. Although any cause-effect relationship remains to be determined, hyperhomocysteinemia as a risk factor for these events suggests that elevated levels of homocysteine may also be a marker of chronic lower limb ulceration. This review addresses the metabolism of homocysteine, mechanisms of vascular injury, a role for hyperhomocysteinemia in lower extremity wounds and possible means of treatment.

Original languageEnglish
Pages (from-to)126-136
Number of pages11
JournalInternational Journal of Lower Extremity Wounds
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2008

Fingerprint

Hyperhomocysteinemia
Homocysteine
Lower Extremity
Wounds and Injuries
Venous Insufficiency
Vascular System Injuries
Venous Thrombosis
Foot
Leg
Atherosclerosis
Cardiovascular Diseases
Pathology

Keywords

  • Folic acid
  • Foot ulcer
  • Hyperhomocysteinemia
  • Leg ulcer
  • Venous insufficiency
  • Vitamin B12

ASJC Scopus subject areas

  • Surgery
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Dermatology

Cite this

Hyperhomocysteinemia and lower extremity wounds. / Schwartzfarb, Elissa M.; Romanelli, Paolo.

In: International Journal of Lower Extremity Wounds, Vol. 7, No. 3, 01.09.2008, p. 126-136.

Research output: Contribution to journalArticle

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