Hyperglycemia and plasmid lipid levels: Covariations in insulin-dependent diabetes

J. M. Sosenko, J. Breslow, O. S. Miettinen, K. H. Gabbay

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Longitudinal relationships of plasma lipids with parameters of blood glucose control were studied in 124 young insulin-dependent diabetic patients who had multiple, simultaneous determinations of these parameters during a 1-yr period. Fluctuations in hemoglobin A1, a cumulative measure of blood glucose control, correlated with fluctuations in total cholesterol (r = 0.19, P < 0.001) and low-density lipoprotein-cholesterol (r = 0.17, P < 0.001). Similarly, fluctuations in fasting blood glucose correlated with those in total cholesterol (r = 0.20, P < 0.001), very low-density lipoprotein-cholesterol (r = 0.13, P = 0.002), and total triglyceride (r = 0.23, P < 0.001). These data indicate covariation between plasma lipid and blood glucose control parameters and suggest that poor blood glucose control contributes to the excess risk of coronary heart disease in insulin-dependent diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalDiabetes care
Issue number1
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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