Hyperglycemia and plasma lipid levels. A prospective study of young insulin-dependent diabetic patients

Jay M Sosenko, J. L. Breslow, O. S. Miettinen, K. H. Gabbay

Research output: Contribution to journalArticle

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Abstract

We explored the relation of plasma lipid levels to the degree of blood glucose control in young, insulin-dependent diabetic patients. Levels of total plasma cholesterol and triglyceride, of their lipoprotein subfractions, and of hemoglobin A1 and fasting blood glucose were measured repeatedly over a one-year period in 105 patients. Lipid levels were also measured in 74 nondiabetic siblings. Increasingly poor control of diabetes, reflected by levels of hemoglobin A1 or of fasting blood glucose, was associated with statistically significant increases in total cholesterol (P≤0.01), total triglyceride (P≤0.007), and lipoprotein subfractions except for high-density lipoprotein cholesterol. Diabetic patients in best control had lipid levels similar to those in their nondiabetic siblings. These data on the relation of plasma lipid levels to diabetic control lend credence to the hypothesis that poor control of blood glucose is conducive to accelerated atherosclerosis in diabetes mellitus.

Original languageEnglish
Pages (from-to)650-654
Number of pages5
JournalNew England Journal of Medicine
Volume302
Issue number12
StatePublished - Jan 1 1980
Externally publishedYes

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Hyperglycemia
Blood Glucose
Prospective Studies
Insulin
Lipids
Lipoproteins
Siblings
Fasting
Hemoglobins
Triglycerides
Cholesterol
HDL Cholesterol
Atherosclerosis
Diabetes Mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hyperglycemia and plasma lipid levels. A prospective study of young insulin-dependent diabetic patients. / Sosenko, Jay M; Breslow, J. L.; Miettinen, O. S.; Gabbay, K. H.

In: New England Journal of Medicine, Vol. 302, No. 12, 01.01.1980, p. 650-654.

Research output: Contribution to journalArticle

Sosenko, Jay M ; Breslow, J. L. ; Miettinen, O. S. ; Gabbay, K. H. / Hyperglycemia and plasma lipid levels. A prospective study of young insulin-dependent diabetic patients. In: New England Journal of Medicine. 1980 ; Vol. 302, No. 12. pp. 650-654.
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