Hypercortisolemia and hippocampal changes in depression

David A. Axelson, P. Murali Doraiswamy, William M. McDonald, Orest B. Boyko, Larry A. Tupler, Linda J. Patterson, Charles Nemeroff, Everett H. Ellinwood, K. Ranga Rama Krishnan

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

Hypercortisolemia is a frequently observed abnormality in patients with major depression. It has been hypothesized that the hippocampus, as a major feedback site for glucocorticoids, is involved in the pathophysiology of hypercortisolemia. Some have in fact posited that the hippocampus is marked by diminished size in depressed patients with hypercortisolemia. We tested this hypothesis by examining the relationship between hippocampal volume, assessed with magnetic resonance imaging, and hypercortisolemia using the dexamethasone suppression test (DST) in a group of 19 depressed patients. No differences in hippocampal volume were observed between patients and control subjects (n = 30). Within the patient group, DST suppressors did not differ from DST nonsuppressors in hippocampal volume. However, a relationship between dhippocampal volume and 11 p.m. cortisol concentration was observed after covariance adjustment for age and sex. Furthermore, significant negative correlations were onserved between hippocampal volume and both age of depressive onset and number of hospitalizations. The results of this study therefore provide limited support for the hypothesis regarding an essential role of the hippocampus in the neuroendocrine elevation of glucocorticoids in depression.

Original languageEnglish
Pages (from-to)163-173
Number of pages11
JournalPsychiatry Research
Volume47
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Dexamethasone
Hippocampus
Glucocorticoids
Age of Onset
Hydrocortisone
Hospitalization
Magnetic Resonance Imaging

Keywords

  • Affective disorder
  • cortisol
  • dexamethasone suppression test
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Axelson, D. A., Doraiswamy, P. M., McDonald, W. M., Boyko, O. B., Tupler, L. A., Patterson, L. J., ... Krishnan, K. R. R. (1993). Hypercortisolemia and hippocampal changes in depression. Psychiatry Research, 47(2), 163-173. https://doi.org/10.1016/0165-1781(93)90046-J

Hypercortisolemia and hippocampal changes in depression. / Axelson, David A.; Doraiswamy, P. Murali; McDonald, William M.; Boyko, Orest B.; Tupler, Larry A.; Patterson, Linda J.; Nemeroff, Charles; Ellinwood, Everett H.; Krishnan, K. Ranga Rama.

In: Psychiatry Research, Vol. 47, No. 2, 01.01.1993, p. 163-173.

Research output: Contribution to journalArticle

Axelson, DA, Doraiswamy, PM, McDonald, WM, Boyko, OB, Tupler, LA, Patterson, LJ, Nemeroff, C, Ellinwood, EH & Krishnan, KRR 1993, 'Hypercortisolemia and hippocampal changes in depression', Psychiatry Research, vol. 47, no. 2, pp. 163-173. https://doi.org/10.1016/0165-1781(93)90046-J
Axelson DA, Doraiswamy PM, McDonald WM, Boyko OB, Tupler LA, Patterson LJ et al. Hypercortisolemia and hippocampal changes in depression. Psychiatry Research. 1993 Jan 1;47(2):163-173. https://doi.org/10.1016/0165-1781(93)90046-J
Axelson, David A. ; Doraiswamy, P. Murali ; McDonald, William M. ; Boyko, Orest B. ; Tupler, Larry A. ; Patterson, Linda J. ; Nemeroff, Charles ; Ellinwood, Everett H. ; Krishnan, K. Ranga Rama. / Hypercortisolemia and hippocampal changes in depression. In: Psychiatry Research. 1993 ; Vol. 47, No. 2. pp. 163-173.
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