Hypercortisolemia and depression

Charles F. Gillespie, Charles B. Nemeroff

Research output: Contribution to journalReview articlepeer-review

256 Scopus citations


Hypercortisolemia and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis are often found in severe forms of depression. The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications.

Original languageEnglish (US)
Pages (from-to)S26-S28
JournalPsychosomatic medicine
Issue numberSUPPL. 1
StatePublished - 2005
Externally publishedYes


  • Corticotropin-releasing factor
  • Cortisol
  • Depression
  • Dexamethasone
  • Hypercortisolemia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)


Dive into the research topics of 'Hypercortisolemia and depression'. Together they form a unique fingerprint.

Cite this