Hypercholesterolaemia in primary cancer of the liver

Ronald B Goldberg, I. Bersohn, M. C. Kew

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumor was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumor. Raised levels were found in 14 of the patients (11%). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.

Original languageEnglish
Pages (from-to)1464-1466
Number of pages3
JournalSouth African Medical Journal
Volume49
Issue number36
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Liver Neoplasms
Hypercholesterolemia
Cholesterol
Experimental Liver Neoplasms
Dietary Cholesterol
Obstructive Jaundice
Neoplasms
Liver
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypercholesterolaemia in primary cancer of the liver. / Goldberg, Ronald B; Bersohn, I.; Kew, M. C.

In: South African Medical Journal, Vol. 49, No. 36, 01.12.1975, p. 1464-1466.

Research output: Contribution to journalArticle

Goldberg, RB, Bersohn, I & Kew, MC 1975, 'Hypercholesterolaemia in primary cancer of the liver', South African Medical Journal, vol. 49, no. 36, pp. 1464-1466.
Goldberg, Ronald B ; Bersohn, I. ; Kew, M. C. / Hypercholesterolaemia in primary cancer of the liver. In: South African Medical Journal. 1975 ; Vol. 49, No. 36. pp. 1464-1466.
@article{7a91ef3a7a324f109e3d3ff778672c4b,
title = "Hypercholesterolaemia in primary cancer of the liver",
abstract = "Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumor was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumor. Raised levels were found in 14 of the patients (11{\%}). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.",
author = "Goldberg, {Ronald B} and I. Bersohn and Kew, {M. C.}",
year = "1975",
month = "12",
day = "1",
language = "English",
volume = "49",
pages = "1464--1466",
journal = "South African Medical Journal",
issn = "0038-2469",
publisher = "South African Medical Association",
number = "36",

}

TY - JOUR

T1 - Hypercholesterolaemia in primary cancer of the liver

AU - Goldberg, Ronald B

AU - Bersohn, I.

AU - Kew, M. C.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumor was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumor. Raised levels were found in 14 of the patients (11%). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.

AB - Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumor was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumor. Raised levels were found in 14 of the patients (11%). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.

UR - http://www.scopus.com/inward/record.url?scp=0016774244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016774244&partnerID=8YFLogxK

M3 - Article

C2 - 169598

AN - SCOPUS:0016774244

VL - 49

SP - 1464

EP - 1466

JO - South African Medical Journal

JF - South African Medical Journal

SN - 0038-2469

IS - 36

ER -