Abstract
Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumor was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumor. Raised levels were found in 14 of the patients (11%). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.
| Original language | English |
|---|---|
| Pages (from-to) | 1464-1466 |
| Number of pages | 3 |
| Journal | South African Medical Journal |
| Volume | 49 |
| Issue number | 36 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
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Cite this
Hypercholesterolaemia in primary cancer of the liver. / Goldberg, Ronald B; Bersohn, I.; Kew, M. C.
In: South African Medical Journal, Vol. 49, No. 36, 01.12.1975, p. 1464-1466.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypercholesterolaemia in primary cancer of the liver
AU - Goldberg, Ronald B
AU - Bersohn, I.
AU - Kew, M. C.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumor was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumor. Raised levels were found in 14 of the patients (11%). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.
AB - Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumor was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumor. Raised levels were found in 14 of the patients (11%). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016774244&partnerID=8YFLogxK
M3 - Article
C2 - 169598
AN - SCOPUS:0016774244
VL - 49
SP - 1464
EP - 1466
JO - South African Medical Journal
JF - South African Medical Journal
SN - 0038-2469
IS - 36
ER -