Hypercalcemia in association with acute renal failure and rhabdomyolysis. Case report and literature review

L. F. Meneghini, J. R. Oster, J. R. Camacho, P. J. Gkonos, B. A. Roos

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The syndrome of hypercalcemia during the course of acute renal failure (usually associated with rhabdomyolysis) occurs most commonly in young men with very severe renal failure. Although fewer than 90 such patients have been reported, the prevalence of hypercalcemia in patients with rhabdomyolysis-associated renal failure averages 30%. Hypercalcemia occurs most commonly in the diuretic phase and resolves spontaneously. The mean duration of hypercalcemia is 14 days. The pathogenesis of this syndrome has not been clearly defined. In the rare instances where it has been measured, intact PTH is suppressed. In contrast, both elevated and suppressed values of plasma 1,25-dihydroxyvitamin D have been reported. The release of calcium from ectopic calcification in damaged muscle tissue provides a potential explanation for this syndrome. Therapy for the hypercalcemia should generally be conservative given its self-limited nature.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalMineral and Electrolyte Metabolism
Volume19
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Rhabdomyolysis
Hypercalcemia
Diuretics
Acute Kidney Injury
Muscle
Tissue
Calcium
Plasmas
Renal Insufficiency
1,25-dihydroxyvitamin D
Muscles

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Meneghini, L. F., Oster, J. R., Camacho, J. R., Gkonos, P. J., & Roos, B. A. (1993). Hypercalcemia in association with acute renal failure and rhabdomyolysis. Case report and literature review. Mineral and Electrolyte Metabolism, 19(1), 1-16.

Hypercalcemia in association with acute renal failure and rhabdomyolysis. Case report and literature review. / Meneghini, L. F.; Oster, J. R.; Camacho, J. R.; Gkonos, P. J.; Roos, B. A.

In: Mineral and Electrolyte Metabolism, Vol. 19, No. 1, 01.01.1993, p. 1-16.

Research output: Contribution to journalArticle

Meneghini, LF, Oster, JR, Camacho, JR, Gkonos, PJ & Roos, BA 1993, 'Hypercalcemia in association with acute renal failure and rhabdomyolysis. Case report and literature review', Mineral and Electrolyte Metabolism, vol. 19, no. 1, pp. 1-16.
Meneghini, L. F. ; Oster, J. R. ; Camacho, J. R. ; Gkonos, P. J. ; Roos, B. A. / Hypercalcemia in association with acute renal failure and rhabdomyolysis. Case report and literature review. In: Mineral and Electrolyte Metabolism. 1993 ; Vol. 19, No. 1. pp. 1-16.
@article{68203b5006f045b7809c4a66209fe354,
title = "Hypercalcemia in association with acute renal failure and rhabdomyolysis. Case report and literature review",
abstract = "The syndrome of hypercalcemia during the course of acute renal failure (usually associated with rhabdomyolysis) occurs most commonly in young men with very severe renal failure. Although fewer than 90 such patients have been reported, the prevalence of hypercalcemia in patients with rhabdomyolysis-associated renal failure averages 30{\%}. Hypercalcemia occurs most commonly in the diuretic phase and resolves spontaneously. The mean duration of hypercalcemia is 14 days. The pathogenesis of this syndrome has not been clearly defined. In the rare instances where it has been measured, intact PTH is suppressed. In contrast, both elevated and suppressed values of plasma 1,25-dihydroxyvitamin D have been reported. The release of calcium from ectopic calcification in damaged muscle tissue provides a potential explanation for this syndrome. Therapy for the hypercalcemia should generally be conservative given its self-limited nature.",
author = "Meneghini, {L. F.} and Oster, {J. R.} and Camacho, {J. R.} and Gkonos, {P. J.} and Roos, {B. A.}",
year = "1993",
month = "1",
day = "1",
language = "English",
volume = "19",
pages = "1--16",
journal = "Mineral and Electrolyte Metabolism",
issn = "0378-0392",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Hypercalcemia in association with acute renal failure and rhabdomyolysis. Case report and literature review

AU - Meneghini, L. F.

AU - Oster, J. R.

AU - Camacho, J. R.

AU - Gkonos, P. J.

AU - Roos, B. A.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The syndrome of hypercalcemia during the course of acute renal failure (usually associated with rhabdomyolysis) occurs most commonly in young men with very severe renal failure. Although fewer than 90 such patients have been reported, the prevalence of hypercalcemia in patients with rhabdomyolysis-associated renal failure averages 30%. Hypercalcemia occurs most commonly in the diuretic phase and resolves spontaneously. The mean duration of hypercalcemia is 14 days. The pathogenesis of this syndrome has not been clearly defined. In the rare instances where it has been measured, intact PTH is suppressed. In contrast, both elevated and suppressed values of plasma 1,25-dihydroxyvitamin D have been reported. The release of calcium from ectopic calcification in damaged muscle tissue provides a potential explanation for this syndrome. Therapy for the hypercalcemia should generally be conservative given its self-limited nature.

AB - The syndrome of hypercalcemia during the course of acute renal failure (usually associated with rhabdomyolysis) occurs most commonly in young men with very severe renal failure. Although fewer than 90 such patients have been reported, the prevalence of hypercalcemia in patients with rhabdomyolysis-associated renal failure averages 30%. Hypercalcemia occurs most commonly in the diuretic phase and resolves spontaneously. The mean duration of hypercalcemia is 14 days. The pathogenesis of this syndrome has not been clearly defined. In the rare instances where it has been measured, intact PTH is suppressed. In contrast, both elevated and suppressed values of plasma 1,25-dihydroxyvitamin D have been reported. The release of calcium from ectopic calcification in damaged muscle tissue provides a potential explanation for this syndrome. Therapy for the hypercalcemia should generally be conservative given its self-limited nature.

UR - http://www.scopus.com/inward/record.url?scp=0027317406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027317406&partnerID=8YFLogxK

M3 - Article

C2 - 8345829

AN - SCOPUS:0027317406

VL - 19

SP - 1

EP - 16

JO - Mineral and Electrolyte Metabolism

JF - Mineral and Electrolyte Metabolism

SN - 0378-0392

IS - 1

ER -