Hyperbaric Oxygen in the Treatment of Radiation-induced Optic Neuropathy

John Guy, Norman J. Schatz

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Four patients with radiation-induced optic neuropathies were treated with hyperbaric oxygen. They had received radiation therapy for treatment of pituitary tumors, reticulum cell sarcoma, and meningioma. Two presented with amaurosis fugax before the onset of unilateral visual loss and began hyperbaria within 72 hours after development of unilateral optic neuropathy. Both had return of visual function to baseline levels. The others initiated treatment two to six weeks after visual loss occurred in the second eye and had no significant improvement of vision. Treatment consisted of daily administration of 100% oxygen under 2.8 atmospheres of pressure for 14-28 days. There were no medical complications of hyperbaria. While hyperbaric oxygen is effective in the treatment of radiation-induced optic neuropathy, it must be instituted within several days of deterioration in vision for restoration of baseline function.

Original languageEnglish (US)
Pages (from-to)1083-1088
Number of pages6
Issue number8
StatePublished - 1986
Externally publishedYes


  • amaurosis fugax
  • hyperbaric oxygen
  • optic neuropathy
  • radiation therapy

ASJC Scopus subject areas

  • Ophthalmology


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