Hyperbaric oxygen and bone marrow-derived endothelial progenitor cells in diabetic wound healing

Katherine A. Gallagher, Lee J. Goldstein, Stephen R. Thom, Omaida C. Velazquez

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations

Abstract

Endothelial progenitor cells (EPCs) are the key cellular effectors of postnatal vasculogenesis and play a central role in wound healing. In diabetes, there is a significant impairment in the number and function of circulating and wound-tissue EPC. Recent evidence indicates, that tissue-level hyperoxia achieved by therapeutic hyperbaric oxygen protocols (HBO2) can increase the mobilization of EPC from the bone marrow into peripheral blood. In this paper we review the recent reports on hyperoxia-mediated mobilization of bone marrow-derived EPC and postulate avenues of future research in this area as it applies to improving healing in chronic wounds affected by diabetes and peripheral arterial disease (PAD).

Original languageEnglish (US)
Pages (from-to)328-337
Number of pages10
JournalVascular
Volume14
Issue number6
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

Keywords

  • Diabetes
  • Endothelial progenitor cells
  • Hyperbaric oxygen
  • Peripheral arterial disease
  • Wounds

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

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