Hyperacute Management of Ischemic Strokes: JACC Focus Seminar

Pratit Patel, Dileep Yavagal, Priyank Khandelwal

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Acute ischemic stroke is the leading cause of disability and among the leading causes of mortality worldwide. Intravenous tissue plasminogen activator has been a cornerstone for treatment of acute ischemic stroke for more than 20 years; however, its use is limited due to a narrow therapeutic window, several contraindications, and low efficacy to recanalize the artery in large vessel occlusion. Recently, the addition of endovascular mechanical thrombectomy of large artery occlusion has revolutionized the stroke treatment for most disabling strokes. The paper reviews updates to the thrombolytic treatment as well as catheter-based treatment, and results from recent trials in the selection of patients in an extended time window using perfusion imaging.

Original languageEnglish (US)
Pages (from-to)1844-1856
Number of pages13
JournalJournal of the American College of Cardiology
Issue number15
StatePublished - Apr 21 2020


  • IV-rtPA
  • acute ischemic stroke
  • imaging in acute stroke
  • mechanical thrombectomy
  • mechanical thrombectomy in extended time window

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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