Abstract
Background: The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion. Observations: We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity. Conclusion: This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers.
| Original language | English |
|---|---|
| Pages (from-to) | 1310-1313 |
| Number of pages | 4 |
| Journal | Archives of Dermatology |
| Volume | 143 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2007 |
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ASJC Scopus subject areas
- Dermatology
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Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix. / Romanelli, Marco; Dini, Valentina; Romanelli, Paolo.
In: Archives of Dermatology, Vol. 143, No. 10, 01.10.2007, p. 1310-1313.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix
AU - Romanelli, Marco
AU - Dini, Valentina
AU - Romanelli, Paolo
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Background: The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion. Observations: We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity. Conclusion: This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers.
AB - Background: The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion. Observations: We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity. Conclusion: This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers.
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UR - http://www.scopus.com/inward/citedby.url?scp=35348952043&partnerID=8YFLogxK
U2 - 10.1001/archderm.143.10.1310
DO - 10.1001/archderm.143.10.1310
M3 - Article
C2 - 17938346
AN - SCOPUS:35348952043
VL - 143
SP - 1310
EP - 1313
JO - JAMA Dermatology
JF - JAMA Dermatology
SN - 2168-6068
IS - 10
ER -