Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix

Marco Romanelli, Valentina Dini, Paolo Romanelli

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion. Observations: We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity. Conclusion: This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers.

Original languageEnglish
Pages (from-to)1310-1313
Number of pages4
JournalArchives of Dermatology
Volume143
Issue number10
DOIs
StatePublished - Oct 1 2007

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Leg Ulcer
Hydroxyurea
Peptide Hydrolases
Matrix Metalloproteinases
oxidized cellulose
Leukocyte Elastase
Fibrinolysin
Porifera
Bandages
Ankle
Collagen
Therapeutics
Wounds and Injuries

ASJC Scopus subject areas

  • Dermatology

Cite this

Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix. / Romanelli, Marco; Dini, Valentina; Romanelli, Paolo.

In: Archives of Dermatology, Vol. 143, No. 10, 01.10.2007, p. 1310-1313.

Research output: Contribution to journalArticle

Romanelli, Marco ; Dini, Valentina ; Romanelli, Paolo. / Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix. In: Archives of Dermatology. 2007 ; Vol. 143, No. 10. pp. 1310-1313.
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