Abstract
OBJECTIVE: To describe a patient with hydroxyurea-induced fever. CASE SUMMARY: A patient with essential thrombocythemia developed a fever 12 hours after beginning hydroxyurea therapy. The diagnosis of drug fever was established by resolution of the fever after withdrawal of hydroxyurea and its recurrence on reexposure to the drug. DISCUSSION: Hydroxyurea-induced fever is rare. In the present case, a short lag period between commencement of hydroxyurea therapy and appearance of fever may suggest either direct toxicity or an idiosyncratic reaction. In previous reports, a hypersensitivity drug reaction was implicated. CONCLUSIONS: The mechanism of hydroxyurea-induced fever remains unclear. Clinicians should be aware of this rare adverse effect.
| Original language | English |
|---|---|
| Pages (from-to) | 132-133 |
| Number of pages | 2 |
| Journal | Annals of Pharmacotherapy |
| Volume | 29 |
| Issue number | 2 |
| State | Published - Jan 1 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Hydroxyurea-induced fever : Case report and review of the literature. / Lossos, Izidore; Matzner, Y.
In: Annals of Pharmacotherapy, Vol. 29, No. 2, 01.01.1995, p. 132-133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hydroxyurea-induced fever
T2 - Case report and review of the literature
AU - Lossos, Izidore
AU - Matzner, Y.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - OBJECTIVE: To describe a patient with hydroxyurea-induced fever. CASE SUMMARY: A patient with essential thrombocythemia developed a fever 12 hours after beginning hydroxyurea therapy. The diagnosis of drug fever was established by resolution of the fever after withdrawal of hydroxyurea and its recurrence on reexposure to the drug. DISCUSSION: Hydroxyurea-induced fever is rare. In the present case, a short lag period between commencement of hydroxyurea therapy and appearance of fever may suggest either direct toxicity or an idiosyncratic reaction. In previous reports, a hypersensitivity drug reaction was implicated. CONCLUSIONS: The mechanism of hydroxyurea-induced fever remains unclear. Clinicians should be aware of this rare adverse effect.
AB - OBJECTIVE: To describe a patient with hydroxyurea-induced fever. CASE SUMMARY: A patient with essential thrombocythemia developed a fever 12 hours after beginning hydroxyurea therapy. The diagnosis of drug fever was established by resolution of the fever after withdrawal of hydroxyurea and its recurrence on reexposure to the drug. DISCUSSION: Hydroxyurea-induced fever is rare. In the present case, a short lag period between commencement of hydroxyurea therapy and appearance of fever may suggest either direct toxicity or an idiosyncratic reaction. In previous reports, a hypersensitivity drug reaction was implicated. CONCLUSIONS: The mechanism of hydroxyurea-induced fever remains unclear. Clinicians should be aware of this rare adverse effect.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028940470&partnerID=8YFLogxK
M3 - Article
VL - 29
SP - 132
EP - 133
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
SN - 1060-0280
IS - 2
ER -