Hydrophilic treatment of porous PTFE for intractable glaucoma implant devices

M. Murahara, Y. Sato, V. Fernandez, F. Fantes, I. Nose, W. Lee, P. Milne, J. M. Parel

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Intractable glaucoma results from hindrances in the eyeball aqueous humor pathways that increase the intraocular pressure above normal physiological levels (over 20mmHg). In this study porous PTFE membranes were made hydrophilic with a photochemical method that use ethyl alcohol and water for the chemical solution. As the surface tension for PTFE is 28.5dyn/cm and for water, 72.3dyn/cm, H2O cannot penetrate in the potes. As ethyl alcohol has a surface tension of 22.6dyn/cm it easily penetrates and, as it has a strong affinity for water, H2O will easily replace the alcohol trapped in the pores. We therefore immersed the sample in ethyl alcohol and then removed it quickly and placed the sample on a paper surface and then added water drops onto the sample for it to penetrate and be trapped in the pores of the e-PTFE membrane. A fused silica glass window was placed over the sample surface forcing the water bubble to form a thin gap between the window and sample surfaces. An ArF excimer laser beam was then used to irradiate the sample. The high-energy photons photo-dissociated the water producing H and OH radicals. Simultaneously, the PTFE was photo-dissociated producing carbon dangling bonds and H radicals. The photo-dissociated OH radicals from the water were substituted to the C's dangling bond of the PTFE. Therefore, the outer and inner surfaces of the PTFE membrane were rendered hydrophilic. We report herein the surface modification technique and the results of preliminary in vivo biocompatibility testing of sample membrane implanted in rabbits.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4245
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Aqueous humor
  • Capillary phenomenon
  • Excimer laser
  • Glaucoma
  • Intraocular pressure
  • Photochemical substitution
  • Porous fluorocarbon

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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