Hybrid antibodies

Seung Uon Shin, Ann Wright, Sherie L. Morrison

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

One of the major advantages of genetic engineering is the ability to produce novel, hybrid antibodies. Hybrid antibodies can be assembled using fragments from different antibodies with the objective of assembling novel combinations of antibody-related effector functions. To efficiently achieve this goal it is necessary to have a precise understanding of the structure-function relationships within the antibody molecule. Secondly, it is possible to produce hybrids of antibodies with non-immunoglobulin proteins thereby achieving unique combination of functional properties. In this case it is necessary to consider both the desired functional properties and the means of assembling the protein components so as to maintain these properties. In all cases it is necessary to have the cloned gene segments, appropriate vectors and expression systems.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalInternational reviews of immunology
Volume10
Issue number2-3
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • Chimeric antibodies
  • Effector function
  • Fusion protein
  • Hybrid antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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