Hyaluronan in the Airways

Rosanna Forteza, Matthias A Salathe, Gregory E Conner

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

In the airway, hyaluronan is not only found in the submucosal, connective tissue compartment, but also on the luminal, ciliated surface of the airway epithelium, as shown by histochemistry of human and ovine tracheal sections using a biotinylated hyaluronan-binding protein. The role of hyaluronan in the airway is likely multifold. Hyaluronan forms a continuous three-dimensional chain network with the ability to absorb and release water, thereby contributing to the hydration and thus, rheological properties of mucus, critical for proper mucociliary function. However, hyaluronan plays other roles in the connective tissue, providing a concentration-dependent osmotic pressure and regulating macromolecular movement by acting as a size-exclusion "gel." Such hyaluronan functions can also be expected in the airways. While hyaluronan is made by airway submucosal gland cells, it is possible that cells of the superficial epithelium, including ciliated cells, contribute to its production. The finding of apically and luminally "secreted" hyaluronan is not unique to the airway. Polarized release of hyaluronan by epithelial cells at the apical surface has been described in retinal, endometrial, and mammary epithelial cells. Removal of hyaluronan from the airway lumen is complex, as at least part of luminal hyaluronan seems protected from mucociliary clearance. Initial breakdown of hyaluronan is required for its removal and this is likely accomplished by ROS.

Original languageEnglish (US)
Title of host publicationChemistry and Biology of Hyaluronan
PublisherElsevier Inc.
Pages323-337
Number of pages15
ISBN (Print)9780080472225, 9780080443829
DOIs
StatePublished - Jul 14 2004

Fingerprint

Hyaluronic Acid
CD44 Antigens
Tissue
Hydration
Gels

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Forteza, R., Salathe, M. A., & Conner, G. E. (2004). Hyaluronan in the Airways. In Chemistry and Biology of Hyaluronan (pp. 323-337). Elsevier Inc.. https://doi.org/10.1016/B978-008044382-9/50046-7

Hyaluronan in the Airways. / Forteza, Rosanna; Salathe, Matthias A; Conner, Gregory E.

Chemistry and Biology of Hyaluronan. Elsevier Inc., 2004. p. 323-337.

Research output: Chapter in Book/Report/Conference proceedingChapter

Forteza, R, Salathe, MA & Conner, GE 2004, Hyaluronan in the Airways. in Chemistry and Biology of Hyaluronan. Elsevier Inc., pp. 323-337. https://doi.org/10.1016/B978-008044382-9/50046-7
Forteza R, Salathe MA, Conner GE. Hyaluronan in the Airways. In Chemistry and Biology of Hyaluronan. Elsevier Inc. 2004. p. 323-337 https://doi.org/10.1016/B978-008044382-9/50046-7
Forteza, Rosanna ; Salathe, Matthias A ; Conner, Gregory E. / Hyaluronan in the Airways. Chemistry and Biology of Hyaluronan. Elsevier Inc., 2004. pp. 323-337
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